Evidence map›Paper›PMID 35098133›Full record

ArticleAdvances in pharmacological and pharmaceutical sciences2022

Mary A Agbenyeku, Regina Appiah-Opong, Ernest Obese, Robert P Biney, Emmanuel A Adakudugu, Arnold D Forkuo, Silas A Osei, Mustapha K Abeka, Elvis O Ameyaw

Open access · goldAbstract read
PubMed Full text at PMC Publisher
In one paragraph

Article in Advances in pharmacological and pharmaceutical sciences, 2022. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 1 paper.

0numbers the graph read from it
0cells of the map it votes in
1citing papers in PubMed
0.4field-weighted citation impact, top 40% of its field
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

1 citing paper in PubMed, 3 citations in OpenAlex.

  1. Investigation of Herb-Drug Interactions betweenAdvances in pharmacological and pharmaceutical sciences · 2024
    Article
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

9 authors at 3 institutions in 1 country.

Mary A AgbenyekuNoguchi Memorial Institute for Medical Research, Department of Clinical Pathology, University of Legon, Accra, Ghana.ORCID https://orcid.org/0000-0002-1855-9959
Regina Appiah-OpongNoguchi Memorial Institute for Medical Research, Department of Clinical Pathology, University of Legon, Accra, Ghana.ORCID https://orcid.org/0000-0003-4219-7107
Ernest ObeseSchool of Pharmacy and Pharmaceutical Sciences, College of Health and Allied Sciences, University of Cape Coast, Ghana.ORCID https://orcid.org/0000-0001-6903-7774
Robert P BineySchool of Pharmacy and Pharmaceutical Sciences, College of Health and Allied Sciences, University of Cape Coast, Ghana.ORCID https://orcid.org/0000-0002-7566-5387
Emmanuel A AdakuduguSchool of Pharmacy and Pharmaceutical Sciences, College of Health and Allied Sciences, University of Cape Coast, Ghana.ORCID https://orcid.org/0000-0002-6254-6397
Arnold D ForkuoFaculty of Pharmacy and Pharmaceutical Sciences, College of Health Sciences, Kwame Nkrumah University of Science and Technology, Kumasi, Ghana.ORCID https://orcid.org/0000-0003-0548-2400
Silas A OseiDepartment of Biomedical Science, School of Allied Health Sciences, College of Health and Allied Sciences, University of Cape Coast, Cape Coast, Ghana.ORCID https://orcid.org/0000-0003-0655-8710
Mustapha K AbekaSchool of Pharmacy and Pharmaceutical Sciences, College of Health and Allied Sciences, University of Cape Coast, Ghana.ORCID https://orcid.org/0000-0002-2869-8266
Elvis O AmeyawSchool of Pharmacy and Pharmaceutical Sciences, College of Health and Allied Sciences, University of Cape Coast, Ghana.ORCID https://orcid.org/0000-0002-8317-9602
University of Cape Coast · GHKwame Nkrumah University of Science and Technology · GHNoguchi Memorial Institute for Medical Research · GH

Funding

No grant is acknowledged in the PubMed record.

6 · The paper itself

Abstract

introductionXylopic acid (XA), the major constituent of the fruit of

methodsInhibition or induction of some isoforms of CYP450 enzymes: CYP 1A1/1A2, 1A2, 2B1/2B2, 3A4, 2D6, and 2C9 were investigated using microsomal fractions of the liver obtained from rats pretreated with a low dose of xylopic acid (LDT) 30 mg/kg, high dose of xylopic acid (HDT) 100 mg/kg, phenobarbitone (PC) 80 mg/kg, and ketoconazole (NC) 100 mg/kg, and a no-treatment group received distilled water, with (

resultsXylopic acid induced CYP 1A1/1A2, 1A2, 2D6, and 2C9, inhibited CYP 3A4, and had no effect on 2B1/2B2.

conclusionThe findings would help mitigate toxicity and therapeutic failure especially in cases of coadministration of medications with food containing XA, with metabolism altered by the latter.

Identifiers

PMID35098133
PMCPMC8799360
OpenAlexW4210545800

What OpenQuestion holds

Textmetadata
LicenceCC BY
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.