Evidence map›Paper›PMID 35098130›Full record

ArticleNeuroscience insights2022

Commentary: How Do Microglia Regulate Neural Circuit Connectivity and Activity in the Adult Brain?

Yong-Jun Liu, Kim N Green, Todd C Holmes, Xiangmin Xu

Open access · goldAbstract readComment
PubMed Full text at PMC Publisher
In one paragraph

Article in Neuroscience insights, 2022. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 2 papers.

0numbers the graph read from it
0cells of the map it votes in
2citing papers in PubMed
0.3field-weighted citation impact, top 44% of its field
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

2 citing papers in PubMed, 4 citations in OpenAlex.

  1. Article
  2. Article
4 · The record

Corrections and comments

5 · Who and what money

Authors and funding

4 authors at 2 institutions in 2 countries.

Yong-Jun LiuKey Laboratory of Pollinating Insect Biology, Institute of Apicultural Research, Chinese Academy of Agricultural Sciences, Beijing, China.ORCID https://orcid.org/0000-0001-6270-5995
Kim N GreenDepartment of Neurobiology and Behavior, University of California, Irvine, CA, USA.
Todd C HolmesDepartment of Physiology and Biophysics, School of Medicine, University of California, Irvine, CA, USA.
Xiangmin XuInstitute for Memory Impairments and Neurological Disorders, University of California, Irvine, CA, USA.
University of California, Irvine · USChinese Academy of Agricultural Sciences · CN

Funding

Origins, properties, and therapeutic potential of cells that repopulate the microglia-depleted adult brainR01NS083801 · NINDS · UNIVERSITY OF CALIFORNIA-IRVINE · PI Kim Green · 2014 to 2026
$5.6M
NINDS NIH HHS R01 NS083801
6 · The paper itself

Abstract

Microglia are the primary immune cells in CNS. Recent work shows that microglia are also essential for proper brain development through synaptic pruning and remodeling during early life development. But the question of whether and how microglia regulate synaptic connectivity in the adult brain remains open. Our recently published study provides new insights into the functional roles of microglia in the adult mouse brain. We find that chronic depletion of microglia via CSF1R inhibitors in the visual cortex in adult mice induces a dramatic increase in perineuronal nets, and enhances neural activities of both excitatory neurons and parvalbumin interneurons. These findings highlight new potential therapeutic avenues to enhance adult neural plasticity by manipulating microglia.

Indexed as

excitatoryMicrogliaparvalbuminplasticityvisual cortex

Identifiers

PMID35098130
PMCPMC8796061
OpenAlexW4206971258

What OpenQuestion holds

Textmetadata
LicenceCC BY-NC
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.