ArticleiScience2022
Sex-dependent features of social behavior differ between distinct laboratory mouse strains and their mixed offspring.
Article in iScience, 2022. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 24 papers, 1 of them a synthesis that pooled it.
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Who cites it
24 citing papers in PubMed, 1 synthesis or guideline pooled it, 35 citations in OpenAlex.
- Pooled it
- Transgenic expression of human signal regulatory protein alpha (SIRPα) in BALB/c Rag2Transgenic research · 2026Article
- The gut microbiome shapes social behaviour across animal species.Nature reviews. Microbiology · 2026Review
- Sex differences in compulsive alcohol drinking phenotypes: implications for decision-making and social behavior in a preclinical model.Psychopharmacology · 2026Article
- Bidirectional regulation of social memory by two distinct types of GABAergic neurons in the lateral septum.Nature communications · 2026Article
- Effects of gestational perfluorohexanesulfonic acid exposure at human realistic dose on social communication deficit in mouse offspring.EBioMedicine · 2026Article
- Heightened empathic responses led by imbalanced cortico-amygdala circuit inbioRxiv : the preprint server for biology · 2025Article
- Article
- Ppp2r1a haploinsufficiency increases excitatory synaptic transmission and decreases spatial learning by impairing endocannabinoid signaling.The Journal of clinical investigation · 2025Article
- Article
- Sex differences in placental structure and gene expression in ICR mice during embryonic development.Scientific reports · 2025Article
- A molecularly defined mPFC-BLA circuit specifically regulates social novelty preference.Science advances · 2025Article
- The Mouse Social Frailty Index (mSFI): A Standardized Protocol.Bio-protocol · 2025Article
- Radioiodine Exhalation Following Oral I-131 Administration in a Mouse Model.Biomedicines · 2025Article
- Impaired emotion recognition in Cntnap2-deficient mice is associated with hyper-synchronous prefrontal cortex neuronal activity.Molecular psychiatry · 2025Article
- Sex- and social context-dependent differences in mice fine head movement during social interactions.BMC biology · 2025Article
- Autistic behavior is a common outcome of biallelic disruption of PDZD8 in humans and mice.Molecular autism · 2025Article
- Environmental enrichment enhances ethanol preference over social reward in male swiss mice: Involvement of oxytocin-dopamine interactions.Neuropharmacology · 2024Article
- Interplay of hippocampal long-term potentiation and long-term depression in enabling memory representations.Philosophical transactions of the Royal Society of London. Series B, Biological sciences · 2024Review
- A prefrontal-thalamic circuit encodes social information for social recognition.Nature communications · 2024Article
Corrections and comments
PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.
Authors and funding
3 authors at 1 institution in 1 country.
Funding
No grant is acknowledged in the PubMed record.
Abstract
The survival of individuals of gregarious species depends on their social interactions. In humans, atypical social behavior is a hallmark of several psychopathological conditions, many of which have sex-specific manifestations. Various laboratory mouse strains are used to reveal the mechanisms mediating typical and atypical social behavior in mammals. Here, we used three social discrimination tests to characterize social behavior in males and females of three widely used laboratory mouse strains (C57BL/6J, BALB/c, and ICR). We found marked sex- and strain-specific differences in the behavior exhibited by subjects, in a test-dependent manner. Interestingly, some characteristics were strain-dependent, while others were sex-dependent. We then crossbred C57BL/6J and BALB/c mice and found that offspring of such crossbreeding exhibit social behavior which differs from both parental strains and depends on the specific combination of parental strains. Thus, social behavior of laboratory mice is sex- and strain-specific and depends on both genetic and environmental factors.
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Registered trials
Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.