ArticleJournal of psychiatry and psychiatric disorders2017
The Role of Brain-Derived Neurotrophic Factor in the Pathophysiology of Psychiatric and Neurological Disorders.
Article in Journal of psychiatry and psychiatric disorders, 2017. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 21 papers.
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Who cites it
21 citing papers in PubMed, 18 citations in OpenAlex.
- Trial
- Comparative gene expression analysis of nestin-expressing hair follicle-derived cells.Scientific reports · 2026Article
- Targeting the BDNF/TrkB/CREB pathway: emerging strategies for neuroprotection in Parkinson's disease.Molecular biology reports · 2026Review
- Therapeutic Effects of MOTS-c in the Valproic Acid-Induced Autism Model in Rats: Role of Tetrahydrobiopterin and Brain-Derived Neurotrophic Factor.Molecular neurobiology · 2026Article
- Synergy between stem cell therapy and brain-derived neurotrophic factor (BDNF) in Parkinson's disease: a mini-review of combined neuroregenerative strategies.Chinese neurosurgical journal · 2025Review
- Plasma and serum BDNF differentially relate to fNIRS prefrontal cortex activity during executive function and memory tasks.Brain research · 2025Article
- Club cell-derived brain-derived neurotrophic factor regulates murine airway mechanics and mucin production in response to IL-13 in a sex-dependent manner.Frontiers in physiology · 2025Article
- From waste to health: exploring the male sexuality enhancing activities of the bioactive components of orange peel.Frontiers in endocrinology · 2025Review
- Association of Sympathovagal Imbalance with Increased Inflammation and Impaired Adaptive Immunity in Bladder Cancer Patients.International journal of molecular sciences · 2024Article
- Article
- Using Precision Medicine to Disentangle Genotype-Phenotype Relationships in Twins with Rett Syndrome: A Case Report.Current issues in molecular biology · 2024Article
- Unlocking new avenues for neuropsychiatric disease therapy: the emerging potential of Peroxisome proliferator-activated receptors as promising therapeutic targets.Psychopharmacology · 2024Review
- Morphogenetic theory of mental and cognitive disorders: the role of neurotrophic and guidance molecules.Frontiers in molecular neuroscience · 2024Review
- Associations of BDNF/BDNF-AS SNPs with Depression, Schizophrenia, and Bipolar Disorder.Journal of personalized medicine · 2023Review
- Article
- Pathophysiology of Major Depression by Clinical Stages.Frontiers in psychology · 2021Article
- Visualization of activity-regulated BDNF expression in the living mouse brain using non-invasive near-infrared bioluminescence imaging.Molecular brain · 2020Article
- Maternal Iron Deficiency Programs Offspring Cognition and Its Relationship with Gastrointestinal Microbiota and Metabolites.International journal of environmental research and public health · 2020Article
- Changes in Cortisol but Not in Brain-Derived Neurotrophic Factor Modulate the Association Between Sleep Disturbances and Major Depression.Frontiers in behavioral neuroscience · 2020Article
- Screening inducers of neuronal BDNF gene transcription using primary cortical cell cultures from BDNF-luciferase transgenic mice.Scientific reports · 2019Article
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Authors and funding
3 authors at 1 institution in 1 country.
Funding
Abstract
Brain-derived neurotrophic factor (BDNF) is a neurotrophin highly expressed in the brain with a potent influence on several aspects of neuronal function. Since its discovery in the early 1980s, BDNF has prompted a great interest in better understanding its physiological role and has been established as the main central neurotrophic factor. BDNF is initially synthesized as a precursor, pro-BDNF, which is then cleaved to form mature BDNF (m-BDNF). A regulated balance between pro-BDNF and m-BDNF is crucial for physiological as well as pathological conditions. The diverse effects of BDNF are mediated through the p75 NT receptor (p75NTR), which binds to its precursor form, and the tropomyosin receptor kinase B (TrkB), which binds to its mature form. Activation of TrkB and p75NTR may produce opposite outcomes in that TrkB receptors have a well-defined trophic role and their activation is proposed to mediate neuronal survival, whereas p75NTR may promote apoptosis. BDNF is highly expressed in limbic structures and cerebral cortex, making it a crucial factor in the regulation of learning and memory, affective behaviors and reward processes. Abnormal BDNF signaling has been proposed to have a crucial role in the course and development of numerous psychiatric and neurological disorders. Moreover, psychotropic drugs used to treat some of these conditions are known to activate BDNF signaling. The present review gives an overview of the involvement of BDNF in the pathology of psychiatric and neurological disorders, compiling what is known from human and animal studies.
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Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.