Evidence map›Paper›PMID 35098037›Full record

ReviewHematology, transfusion and cell therapy

Dysregulation in erythrocyte dynamics caused by SARS-CoV-2 infection: possible role in shuffling the homeostatic puzzle during COVID-19.

Michelle Mendanha Mendonça, Kellen Rosa da Cruz, Denise da Silva Pinheiro, Gean Carlos Alves Moraes, Patricia Maria Ferreira, Marcos Luiz Ferreira-Neto, Eduardo Sérgio da Silva, Reggiani Vilela Gonçalves, Gustavo Rodrigues Pedrino, James O Fajemiroye and 1 more

Abstract readReview
In one paragraph

Review in Hematology, transfusion and cell therapy. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 8 papers.

0numbers the graph read from it
0cells of the map it votes in
8citing papers in PubMed
–field-weighted citation impact
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

8 citing papers in PubMed.

  1. Article
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4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

11 authors.

Michelle Mendanha MendonçaInstituto de Ciências Biológicas da Universidade Federal de Goiás (UFG), Goiânia, GO, Brazil.
Kellen Rosa da CruzInstituto de Ciências Biológicas da Universidade Federal de Goiás (UFG), Goiânia, GO, Brazil.
Denise da Silva PinheiroInstituto de Ciências Biológicas da Universidade Federal de Goiás (UFG), Goiânia, GO, Brazil.
Gean Carlos Alves MoraesInstituto de Ciências Biológicas da Universidade Federal de Goiás (UFG), Goiânia, GO, Brazil.
Patricia Maria FerreiraInstituto de Ciências Biológicas da Universidade Federal de Goiás (UFG), Goiânia, GO, Brazil.
Marcos Luiz Ferreira-NetoInstituto de Ciências Biomédicas da Universidade Federal de Uberlândia (ICBIM UFU), Uberlândia, MG, Brazil.
Eduardo Sérgio da SilvaUniversidade Federal de São João Del-Rei (UFSJ), Divinópolis, MG, Brazil.
Reggiani Vilela GonçalvesUniversidade Federal de Viçosa (UFV), Viçosa, MG, Brazil.
Gustavo Rodrigues PedrinoInstituto de Ciências Biológicas da Universidade Federal de Goiás (UFG), Goiânia, GO, Brazil.
James O FajemiroyeInstituto de Ciências Biológicas da Universidade Federal de Goiás (UFG), Goiânia, GO, Brazil.
Carlos Henrique XavierInstituto de Ciências Biológicas da Universidade Federal de Goiás (UFG), Goiânia, GO, Brazil. Electronic address: carlosxavier@ufg.br.

Funding

No grant is acknowledged in the PubMed record.

6 · The paper itself

Abstract

Introduction: The evolving COVID-19 pandemic became a hallmark in human history, not only by changing lifestyles, but also by enriching scientific knowledge on viral infection and its consequences. Objective: Although the management of cardiorespiratory changes is pivotal to a favorable prognosis during severe clinical findings, dysregulation of other systems caused by SARS-CoV-2 infection may imbalance erythrocyte dynamics, such as a bidirectional positive feedback loop pathophysiology. Method and Results: Recent evidence shows that SARS-CoV-2 is capable of affecting the genetics and dynamics of erythrocytes and this coexists with a non-homeostatic function of cardiovascular, respiratory and renal systems during COVID-19. In hypothesis, SARS-CoV-2-induced systematical alterations of erythrocytes dynamics would constitute a setpoint for COVID-19-related multiple organ failure syndrome and death. Conclusion: The present review covers the most frequent erythrocyte-related non-homeostatic findings during COVID-19 capable of providing mechanistic clues of SARS-CoV-2-induced infection and inspiring therapeutic-oriented scientific evidence.

Indexed as

COVID-19ErythrocyteHemoglobinHemorphinsSARS-CoV-2

Identifiers

PMID35098037
PMCPMC8786672

What OpenQuestion holds

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Registered trials

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Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.