Evidence map›Paper›PMID 35097417›Full record

ArticleFoot & ankle orthopaedics2020

Tranexamic Acid Use in Foot and Ankle Surgery.

William L Johns, Kempland C Walley, Raees Seedat, Benjamin Jackson, Karim Boukhemis, Tyler Gonzalez

Open access · goldAbstract read
PubMed Full text at PMC Publisher
In one paragraph

Article in Foot & ankle orthopaedics, 2020. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 5 papers, 1 of them a synthesis that pooled it.

0numbers the graph read from it
0cells of the map it votes in
5citing papers in PubMed, 1 pooled it
0.6field-weighted citation impact, top 40% of its field
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

5 citing papers in PubMed, 1 synthesis or guideline pooled it, 10 citations in OpenAlex.

  1. Pooled it
  2. Trial
  3. Review
  4. Article
  5. Plasmin, Immunity, and Surgical Site Infection.Journal of clinical medicine · 2021
    Review
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

6 authors at 5 institutions in 1 country.

William L JohnsRothman Orthopaedic Institute, Thomas Jefferson University Hospital, Philadelphia, PA, USA.ORCID https://orcid.org/0000-0001-9939-7447
Kempland C WalleyDepartment of Orthopaedic Surgery, University of Michigan, Michigan Medicine, Ann Arbor, MI, USA.ORCID https://orcid.org/0000-0003-4488-0663
Raees SeedatVirginia Commonwealth University, School of Medicine, Richmond, VA, USA.
Benjamin JacksonUniversity of South Carolina, School of Medicine, Columbia, SC, USA.ORCID https://orcid.org/0000-0002-9444-087X
Karim BoukhemisScott Orthopedic Center, Huntington, WV, USA.
Tyler GonzalezUniversity of South Carolina, School of Medicine, Columbia, SC, USA.ORCID https://orcid.org/0000-0002-3210-8097
University of South Carolina · USMichigan Medicine · USOrthopedic Center · USThomas Jefferson University Hospital · USVirginia Commonwealth University · US

Funding

No grant is acknowledged in the PubMed record.

6 · The paper itself

Abstract

backgroundThere is a potential role for tranexamic acid (TXA) use in foot and ankle procedures; however, the benefits of this intervention have not been fully elucidated. The purpose of this study was to explore the safety, outcomes, and medical complication profile of the use of intravenous TXA in patients undergoing foot and ankle surgery.

methodsA prospective study with retrospective review of 241 patients undergoing elective and traumatic foot and ankle procedures was performed. One gram of intravenous (IV) TXA was administered prior to incision. Patients were followed and evaluated for medical comorbidities, intraoperative blood loss, wound complication, superficial and deep infections, hematoma formation, medical complications, 30-day hospital readmission rate, and return visits to the emergency department or urgent care setting prior to first postoperative visit. Descriptive statistics were used for subgroup analysis. Mean postoperative follow-up was 4.5 months.

resultsEstimated blood loss in all cases was less than 20 mL. There was 1 case of superficial cellulitis (1/241, 0.4%), 1 deep infection after Achilles tendon repair (1/241, 0.4%), 4 cases of delayed wound healing (4/241, 1.6%), 1 instance of deep vein thrombosis (1/241, 0.4%), and 2 cases of postoperative pulmonary embolism (2/241, 0.8%). There were no instances of postoperative hematoma formation. There were no additional recorded thromboembolic events. There were no adverse drug reactions. There were no 30-day hospital readmissions or return visits to the emergency department or urgent care setting before the first postoperative visit. In a subgroup analysis, there was no significant difference in wound complications or infections between nondiabetics and diabetics (

conclusionsThe use of IV TXA in foot and ankle surgeries was associated with low risk of wound complications, infections, hematoma formation, thromboembolic events, and overall complication rates with minimal side effect profile. Perioperative tranexamic acid use may prove to be beneficial in foot and ankle surgery patients but especially in higher-risk patients such as those with diabetes, trauma, and those that are immunocompromised. LEVEL OF EVIDENCE: Level IV, case series.

Indexed as

tranexamic acidwound complications

Identifiers

PMID35097417
PMCPMC8564923
OpenAlexW3112510397

What OpenQuestion holds

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LicenceCC BY-NC
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Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.