Evidence map›Paper›PMID 35097151›Full record

ArticleOpen forum infectious diseases2022

Pre-exposure Prophylaxis Recent Adherence With Real-Time Adherence Feedback and Partner Human Immunodeficiency Virus Self-Testing: A Pilot Trial Among Postpartum Women.

Dvora Leah Joseph Davey, Kathryn Dovel, Rufaro Mvududu, Dorothy Nyemba, Nyiko Mashele, Linda-Gail Bekker, Pamina M Gorbach, Thomas J Coates, Landon Myer

2 registry-linked trialsOpen access · goldAbstract read
PubMed Full text at PMC Publisher
In one paragraph

Article in Open forum infectious diseases, 2022. The graph could read no effect estimate from its abstract, so it casts no vote on the map. It is linked to 2 registered trials, which are not on this map. Cited by 18 papers, 2 of them syntheses that pooled it.

0numbers the graph read from it
0cells of the map it votes in
18citing papers in PubMed, 2 pooled it
0.9field-weighted citation impact, top 22% of its field
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

NCT03902418 completednot on this map

Evaluation of Pre-Exposure Prophylaxis (PrEP) Initiation, Retention, and Adherence in Pregnant and Breastfeeding Women

TypeobservationalSponsorUniversity of California, Los AngelesRan2019 to 2024Enrolled1,195ConditionsHIV-I InfectionArmsemtricitabine/tenofovir
NCT04897737 nacompletednot on this map

Study of the Feasibility and Acceptability of an Adherence Promotion Package for Postpartum Women on Pre-exposure Prophylaxis (PrEP)

TypeinterventionalSponsorUniversity of California, Los AngelesRan2020 to 2021Enrolled106ConditionsHIV-1-infectionArmsHIVST and enhanced adherence biofeedback, Orasure/UrSure test
3 · Its place in the literature

Who cites it

18 citing papers in PubMed, 2 syntheses or guidelines pooled it, 23 citations in OpenAlex.

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4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

9 authors at 3 institutions in 2 countries.

Dvora Leah Joseph DaveyDepartment of Epidemiology, Fielding School of Public Health, University of California Los Angeles, Los Angeles, California, USA.ORCID https://orcid.org/0000-0001-6290-9293
Kathryn DovelDivision of Infectious Diseases, David Geffen School of Medicine, University of California Los Angeles, Los Angeles, California, USA.
Rufaro MvududuDivision of Epidemiology and Biostatistics, School of Public Health and Family Medicine, University of Cape Town, Cape Town, South Africa.
Dorothy NyembaDivision of Epidemiology and Biostatistics, School of Public Health and Family Medicine, University of Cape Town, Cape Town, South Africa.
Nyiko MasheleDivision of Epidemiology and Biostatistics, School of Public Health and Family Medicine, University of Cape Town, Cape Town, South Africa.
Linda-Gail BekkerThe Desmond Tutu HIV Centre, University of Cape Town, Cape Town, South Africa.
Pamina M GorbachDepartment of Epidemiology, Fielding School of Public Health, University of California Los Angeles, Los Angeles, California, USA.
Thomas J CoatesDivision of Infectious Diseases, David Geffen School of Medicine, University of California Los Angeles, Los Angeles, California, USA.
Landon MyerDivision of Epidemiology and Biostatistics, School of Public Health and Family Medicine, University of Cape Town, Cape Town, South Africa.
University of Cape Town · ZAUniversity of California, Los Angeles · USDesmond Tutu HIV Foundation · ZA

Funding

Evaluating the PrEP cascade in HIV-negative pregnant and breastfeeding women in South Africa (PrEP-PP)R01MH116771 · NIMH · UNIVERSITY OF CALIFORNIA LOS ANGELES · PI JOSEPH DAVEY, DVORA LEAH, MYER, BENJAMIN LANDON · 2018 to 2022
$2.5M
Evaluation of pre-exposure prophylaxis cascade in pregnant and breastfeeding women in Cape Town, South AfricaK01TW011187 · FIC · UNIVERSITY OF CALIFORNIA LOS ANGELES · PI JOSEPH DAVEY, DVORA LEAH · 2018 to 2022
$698k
FIC NIH HHS K01 TW011187NIMH NIH HHS R01 MH116771
6 · The paper itself

Abstract

backgroundPre-exposure prophylaxis (PrEP) is safe and effective in postpartum women. Human immunodeficiency virus self-testing (HIVST) for male partners combined with biofeedback counseling through real-time adherence measures may improve PrEP use among postpartum women.

methodsBetween August 2020 and April 2021, we randomized postpartum women who initiated PrEP in pregnancy 1:1 to the intervention group (HIVST + biofeedback counseling after urine tenofovir test) or to standard of care ([SOC] facility-based human immunodeficiency virus [HIV] tests and routine counseling without biofeedback). The outcomes of interest were PrEP adherence in the past 48-72 hours via urine tenofovir tests and partner HIV testing, measured 1-month after randomization. Secondary outcomes included the proportion of partners who tested for HIV and the discrepancy between self-reported PrEP adherence and urine tenofovir result.

resultsWe enrolled 106 women (median age = 26 years). At enrollment, 72% of women reported missing <2 doses in the past 7 days; 36% of women had tenofovir present in her urine. One month after enrollment, 62% (n = 33) of women in the intervention arm had tenofovir present in their urine compared to 34% (n = 18) in SOC (risk ratio [RR] = 1.83; 95% confidence interval [CI] = 1.19-2.82;

conclusionsThe HIVST for partners and biofeedback counseling increased levels of recent PrEP adherence, pointing to the importance of these interventions to support PrEP use in this population.

Indexed as

adherencebreastfeedingpre-exposure prophylaxispregnantSouth Africa

Identifiers

PMID35097151
PMCPMC8794072
OpenAlexW4200552797

What OpenQuestion holds

Textmetadata
LicenceCC BY-NC-ND
Read underepoch 390

Registered trials

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.