Evidence map›Paper›PMID 35097028›Full record

ArticleFrontiers in cardiovascular medicine2021

Autoimmune Regulator (AIRE) Deficiency Does Not Affect Atherosclerosis and CD4 T Cell Immune Tolerance to Apolipoprotein B.

Felix Sebastian Nettersheim, Simon Braumann, Kouji Kobiyama, Marco Orecchioni, Melanie Vassallo, Jacqueline Miller, Amal Ali, Payel Roy, Ryosuke Saigusa, Dennis Wolf and 2 more

Open access · goldAbstract read
In one paragraph

Article in Frontiers in cardiovascular medicine, 2021. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 5 papers.

0numbers the graph read from it
0cells of the map it votes in
5citing papers in PubMed
0.4field-weighted citation impact, top 44% of its field
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

5 citing papers in PubMed, 5 citations in OpenAlex.

  1. PD-1 and CD73 on naive CD4Nature immunology · 2025
    Article
  2. Review
  3. Article
  4. Article
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4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

12 authors at 5 institutions in 2 countries.

Felix Sebastian NettersheimDepartment of Cardiology, University Hospital Cologne, Cologne, Germany.
Simon BraumannDepartment of Cardiology, University Hospital Cologne, Cologne, Germany.
Kouji KobiyamaLa Jolla Institute for Immunology, La Jolla, CA, United States.
Marco OrecchioniLa Jolla Institute for Immunology, La Jolla, CA, United States.
Melanie VassalloLa Jolla Institute for Immunology, La Jolla, CA, United States.
Jacqueline MillerLa Jolla Institute for Immunology, La Jolla, CA, United States.
Amal AliLa Jolla Institute for Immunology, La Jolla, CA, United States.
Payel RoyLa Jolla Institute for Immunology, La Jolla, CA, United States.
Ryosuke SaigusaLa Jolla Institute for Immunology, La Jolla, CA, United States.
Dennis WolfDepartment of Cardiology and Angiology I, University Hospital Freiburg, Freiburg, Germany.
Klaus LeyLa Jolla Institute for Immunology, La Jolla, CA, United States.
Holger WinkelsDepartment of Cardiology, University Hospital Cologne, Cologne, Germany.
La Jolla Institute for Immunology · USUniversity of Cologne · DEUniversity Hospital Cologne · DEUniversity Medical Center Freiburg · DEUniversity of California, San Diego · US

Funding

Transcriptional GenomicsP01HL088093 · NHLBI · UNIVERSITY OF CALIFORNIA, SAN DIEGO · PI WITZTUM, JOSEPH L. · 2008 to 2018
$26.4M
Myeloid cell interactions with T cells in atherosclerosisR01HL115232 · NHLBI · LA JOLLA INSTITUTE FOR IMMUNOLOGY · PI LEY, KLAUS F. · 2012 to 2018
$3.2M
Vaccination with MHC-II restricted ApoB100 peptides to prevent atherosclerosisR01HL121697 · NHLBI · LA JOLLA INSTITUTE FOR IMMUNOLOGY · PI LEY, KLAUS F. · 2015 to 2018
$1.8M
NHLBI NIH HHS P01 HL088093NHLBI NIH HHS R01 HL115232NHLBI NIH HHS R01 HL121697
6 · The paper itself

Abstract

Atherosclerosis is a chronic, lipid-driven disease of medium sized arteries which causes myocardial infarction and stroke. Recently, an adaptive immune response against the plaque-associated autoantigen Apolipoprotein B100 (ApoB), the structural protein component of low-density lipoprotein, has been implicated in atherogenesis. In healthy individuals, CD4

Indexed as

adaptive immunityantigen-specificatherosclerosisautoimmune regulatordextramerimmune toleranceT cellsthymic selection

Identifiers

PMID35097028
PMCPMC8792778
OpenAlexW4205489584

What OpenQuestion holds

Textmetadata
LicenceCC BY
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.