ArticleFrontiers in cardiovascular medicine2021
Trpc6 Promotes Doxorubicin-Induced Cardiomyopathy in Male Mice With Pleiotropic Differences Between Males and Females.
Open access · goldAbstract read
In one paragraph
Article in Frontiers in cardiovascular medicine, 2021. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 17 papers.
0numbers the graph read from it
0cells of the map it votes in
17citing papers in PubMed
2.8field-weighted citation impact, top 9% of its field
What it found
Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.
The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.
The trial behind it
Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.
Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.
Who cites it
17 citing papers in PubMed, 20 citations in OpenAlex.
- Functional evaluation of TRPC6 missense variants in cancer patients via molecular docking analysis compared with patch Clamp electrophysiology.The Journal of biological chemistry · 2026Article
- Gain-of-Function VariantCirculation. Genomic and precision medicine · 2026Article
- Review
- Functional Evaluation ofbioRxiv : the preprint server for biology · 2026Article
- Understanding the Mechanisms of Chemotherapy-Related Cardiotoxicity Employing hiPSC-Derived Cardiomyocyte Models for Drug Screening and the Identification of Genetic and Epigenetic Variants.International journal of molecular sciences · 2025Review
- Distinct Impact of Doxorubicin on Skeletal Muscle and Fat Metabolism in Mice: Without Dexrazoxane Effect.International journal of molecular sciences · 2025Article
- Article
- Computational approaches identify a transcriptomic fingerprint of drug-induced structural cardiotoxicity.Cell biology and toxicology · 2024Article
- Sex-related differences in delayed doxorubicin-induced cardiac dysfunction in C57BL/6 mice.Archives of toxicology · 2024Article
- [Platycodin D improves pulmonary fibrosis in mice by down-regulating TRPC6 expression and reducing ROS production in lung fibroblasts].Nan fang yi ke da xue xue bao = Journal of Southern Medical University · 2024Article
- Research summary of poster presentations at the 2023 Florida cardio-oncology symposium.American heart journal plus : cardiology research and practice · 2024Article
- Reconstituted Extracellular Vesicles from Human Platelets Decrease Viral Myocarditis in Mice.Small (Weinheim an der Bergstrasse, Germany) · 2023Article
- Doxorubicin-induced cardiovascular toxicity: a longitudinal evaluation of functional and molecular markers.Cardiovascular research · 2023Article
- Modeling Cardiotoxicity in Pediatric Oncology Patients Using Patient-Specific iPSC-Derived Cardiomyocytes Reveals Downregulation of Cardioprotective microRNAs.Antioxidants (Basel, Switzerland) · 2023Article
- Replication of genetic associations of chemotherapy-related cardiotoxicity in the adjuvant NSABP B-31 clinical trial.Frontiers in oncology · 2023Article
- Dexrazoxane does not mitigate early vascular toxicity induced by doxorubicin in mice.PloS one · 2023Article
- TRPC6 N338S is a gain-of-function mutant identified in patient with doxorubicin-induced cardiotoxicity.Biochimica et biophysica acta. Molecular basis of disease · 2022Article
Corrections and comments
PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.
Authors and funding
22 authors at 2 institutions in 1 country.
Nadine NortonDepartment of Cancer Biology, Mayo Clinic, Jacksonville, FL, United States.
Katelyn A BrunoDepartment of Cardiovascular Medicine, Mayo Clinic, Jacksonville, FL, United States.
Damian N Di FlorioDepartment of Cardiovascular Medicine, Mayo Clinic, Jacksonville, FL, United States.
Emily R WhelanDepartment of Cardiovascular Medicine, Mayo Clinic, Jacksonville, FL, United States.
Anneliese R HillDepartment of Cardiovascular Medicine, Mayo Clinic, Jacksonville, FL, United States.
Andrea Carolina Morales-LaraDepartment of Cardiovascular Medicine, Mayo Clinic, Jacksonville, FL, United States.
Anna A MeaseDepartment of Cardiovascular Medicine, Mayo Clinic, Jacksonville, FL, United States.
John M SousouDepartment of Cardiovascular Medicine, Mayo Clinic, Jacksonville, FL, United States.
Jose A MalavetDepartment of Cardiovascular Medicine, Mayo Clinic, Jacksonville, FL, United States.
Lauren E DornDepartment of Cardiovascular Medicine, Mayo Clinic, Jacksonville, FL, United States.
Gary R SalomonDepartment of Cardiovascular Medicine, Mayo Clinic, Jacksonville, FL, United States.
Logan P MacombDepartment of Cardiovascular Medicine, Mayo Clinic, Jacksonville, FL, United States.
Sami KhatibDepartment of Cardiovascular Medicine, Mayo Clinic, Jacksonville, FL, United States.
Zacharias P AnastasiadisDepartment of Cancer Biology, Mayo Clinic, Jacksonville, FL, United States.
Brian M NecelaDepartment of Cancer Biology, Mayo Clinic, Jacksonville, FL, United States.
Molly M McGuireDepartment of Cardiovascular Medicine, Mayo Clinic, Jacksonville, FL, United States.
Presley G GiresiDepartment of Cardiovascular Medicine, Mayo Clinic, Jacksonville, FL, United States.
Archana KothaDepartment of Cardiovascular Medicine, Mayo Clinic, Jacksonville, FL, United States.
Danielle J BeetlerDepartment of Cardiovascular Medicine, Mayo Clinic, Jacksonville, FL, United States.
Raegan M WeilDepartment of Cancer Biology, Mayo Clinic, Jacksonville, FL, United States.
Carolyn K LandolfoDepartment of Cardiovascular Medicine, Mayo Clinic, Jacksonville, FL, United States.
DeLisa FairweatherDepartment of Cardiovascular Medicine, Mayo Clinic, Jacksonville, FL, United States.
Mayo Clinic in Florida · USWinnMed · US
Funding
Characterization of TRPC6 to predict and prevent chemotherapy-related heart failureR56HL160643 · NHLBI · MAYO CLINIC JACKSONVILLE · PI NORTON, NADINE · 2022 to 2022
$498kRole of viral mitophagosomes in driving sex differences in myocarditisR21AI145356 · NIAID · MAYO CLINIC JACKSONVILLE · PI FAIRWEATHER, DELISA, SIN, JON · 2019 to 2020
$463kAdipose-derived biogenic nanoparticles for treatment of myocarditis/DCM(MPDPI)R21AI152318 · NIAID · MAYO CLINIC JACKSONVILLE · PI FAIRWEATHER, DELISA, WOLFRAM, JOY · 2020 to 2021
$430kSex differences in exercise-induced mitochondrial function during viral myocarditisR21AI154927 · NIAID · MAYO CLINIC JACKSONVILLE · PI FAIRWEATHER, DELISA · 2020 to 2021
$403kNHLBI NIH HHS R56 HL160643NIAID NIH HHS R21 AI145356NIAID NIH HHS R21 AI152318NIAID NIH HHS R21 AI154927
Abstract
PubMed holds no abstract for this paper.
Indexed as
anthracyclinecardiotoxicityheart failureion channelsex differencesTRPC
Identifiers
What OpenQuestion holds
Textmetadata
LicenceCC BY
Read underepoch 390
Registered trials
None linked
Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.