Evidence map›Paper›PMID 35096884›Full record

ArticleFrontiers in medicine2021

Molecular Imaging of Lower Extremity Peripheral Arterial Disease: An Emerging Field in Nuclear Medicine.

Mitchel R Stacy

Registry-linked trialOpen access · goldAbstract read
In one paragraph

Article in Frontiers in medicine, 2021. The graph could read no effect estimate from its abstract, so it casts no vote on the map. It is linked to trial NCT03622359 (Radiotracer Imaging of Skeletal Muscle Perfusion in Patients With Peripheral Artery Disease), which is not on this map. Cited by 9 papers.

0numbers the graph read from it
0cells of the map it votes in
9citing papers in PubMed
2.2field-weighted citation impact, top 13% of its field
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

NCT03622359 narecruitingnot on this map

Radiotracer Imaging of Skeletal Muscle Perfusion in Patients With Peripheral Artery Disease

TypeinterventionalSponsorNationwide Children's HospitalRan2017 to 2028Enrolled192ConditionsPeripheral Artery Disease, Diabetes Mellitus, Chronic Limb-Threatening IschemiaArmsSPECT/CT perfusion imaging, PET/CT perfusion imaging
3 · Its place in the literature

Who cites it

9 citing papers in PubMed, 10 citations in OpenAlex.

  1. Trial
  2. Article
  3. Lower Extremity Flow Quantification Using DynamicIEEE transactions on radiation and plasma medical sciences · 2025
    Article
  4. Review
  5. Article
  6. Article
  7. Review
  8. Article
  9. Article
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

1 author at 1 institution in 1 country.

Mitchel R StacyCenter for Regenerative Medicine, The Research Institute at Nationwide Children's Hospital, Columbus, OH, United States.
Nationwide Children's Hospital · US

Funding

Radiotracer-Based Imaging for Quantitative Assessment of Skeletal Muscle Perfusion in Peripheral Artery DiseaseR01HL135103 · NHLBI · YALE UNIVERSITY · PI Mitchel R Stacy · 2017 to 2026
$3.8M
NHLBI NIH HHS R01 HL135103
6 · The paper itself

Abstract

Peripheral arterial disease (PAD) is an atherosclerotic disorder of non-coronary arteries that is associated with vascular stenosis and/or occlusion. PAD affecting the lower extremities is characterized by a variety of health-related consequences, including lifestyle-limiting intermittent claudication, ulceration of the limbs and/or feet, increased risk for lower extremity amputation, and increased mortality. The diagnosis of lower extremity PAD is typically established by using non-invasive tests such as the ankle-brachial index, toe-brachial index, duplex ultrasound, and/or angiography imaging studies. While these common diagnostic tools provide hemodynamic and anatomical vascular assessments, the potential for non-invasive physiological assessment of the lower extremities has more recently emerged through the use of magnetic resonance- and nuclear medicine-based approaches, which can provide insight into the functional consequences of PAD-related limb ischemia. This perspectives article specifically highlights and discusses the emerging applications of clinical nuclear medicine techniques for molecular imaging investigations in the setting of lower extremity PAD.

Indexed as

computed tomographymolecular imagingperipheral arterial disease (PAD)positron emission tomography (PET)single photon emission computed tomography (SPECT)

Identifiers

PMID35096884
PMCPMC8789656
OpenAlexW4205396515

What OpenQuestion holds

Textmetadata
LicenceCC BY
Read underepoch 390

Registered trials

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.