Evidence map›Paper›PMID 35096818›Full record

ArticleFrontiers in cell and developmental biology2021

Gfi1aa/Lsd1 Facilitates Hemangioblast Differentiation Into Primitive Erythrocytes by Targeting

Mei Wu, Qi Chen, Jing Li, Yue Xu, Junwei Lian, Yongxiang Liu, Ping Meng, Yiyue Zhang

Open access · goldAbstract read
PubMed Full text at PMC Publisher
In one paragraph

Article in Frontiers in cell and developmental biology, 2021. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 2 papers.

0numbers the graph read from it
0cells of the map it votes in
2citing papers in PubMed
0.5field-weighted citation impact, top 39% of its field
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

2 citing papers in PubMed, 4 citations in OpenAlex.

  1. Review
  2. Article
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

8 authors at 3 institutions in 2 countries.

Mei WuDivision of Cell, Developmental and Integrative Biology, School of Medicine, South China University of Technology, Guangzhou, China.
Qi ChenShenzhen Key Laboratory for Neuronal Structural Biology, Biomedical Research Institute, Shenzhen Peking University-The Hong Kong University of Science and Technology Medical Center, Shenzhen, China.
Jing LiDivision of Cell, Developmental and Integrative Biology, School of Medicine, South China University of Technology, Guangzhou, China.
Yue XuDivision of Cell, Developmental and Integrative Biology, School of Medicine, South China University of Technology, Guangzhou, China.
Junwei LianDivision of Cell, Developmental and Integrative Biology, School of Medicine, South China University of Technology, Guangzhou, China.
Yongxiang LiuDepartment of Developmental Biology, School of Basic Medical Sciences, Southern Medical University, Guangzhou, China.
Ping MengDepartment of Developmental Biology, School of Basic Medical Sciences, Southern Medical University, Guangzhou, China.
Yiyue ZhangDivision of Cell, Developmental and Integrative Biology, School of Medicine, South China University of Technology, Guangzhou, China.
South China University of Technology · CNSouthern Medical University · CNHong Kong University of Science and Technology · HK

Funding

No grant is acknowledged in the PubMed record.

6 · The paper itself

Abstract

The first wave of hematopoiesis is the primitive hematopoiesis, which produces embryonic erythroid and myeloid cells. Primitive erythrocytes are thought to be generated from bipotent hemangioblasts, but the molecular basis remains unclear. Transcriptional repressors Gfi1aa and Gfi1b have been shown to cooperatively promote primitive erythrocytes differentiation from hemangioblasts in zebrafish. However, the mechanism of these repressors during the primitive wave is largely unknown. Herein, by functional analysis of zebrafish

Indexed as

etv2Gfi1aahemangioblast differentiationprimitive erythrocytesox7zebrafish

Identifiers

PMID35096818
PMCPMC8790037
OpenAlexW4210591132

What OpenQuestion holds

Textmetadata
LicenceCC BY
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.