Evidence map›Paper›PMID 35096778›Full record

ArticleFrontiers in chemistry2021

Design of a Controlled-Release Delivery Composite of Antibacterial Agent Gatifloxacin by Spherical Silica Nanocarrier.

Xueping Guo, Wenjing Mo, Dingyang Zhang, Yurong Wang, Fang Cao, Tianyun Zhai, Wenhua Rao, Xiong Guan, Lei Xu, Xiaohong Pan

Open access · goldAbstract read
PubMed Full text at PMC Publisher
In one paragraph

Article in Frontiers in chemistry, 2021. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Not yet cited in PubMed.

0numbers the graph read from it
0cells of the map it votes in
0citing papers in PubMed
0.3field-weighted citation impact, top 49% of its field
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

0 citing papers in PubMed, 4 citations in OpenAlex.

No citing paper in PubMed yet.

4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

10 authors at 2 institutions in 1 country.

Xueping GuoState Key Laboratory of Ecological Pest Control for Fujian and Taiwan Crops and Key Lab of Biopesticide and Chemical Biology, Ministry of Education and College of Plant Protection, Fujian Agriculture and Forestry University, Fuzhou, China.
Wenjing MoState Key Laboratory of Ecological Pest Control for Fujian and Taiwan Crops and Key Lab of Biopesticide and Chemical Biology, Ministry of Education and College of Plant Protection, Fujian Agriculture and Forestry University, Fuzhou, China.
Dingyang ZhangState Key Laboratory of Ecological Pest Control for Fujian and Taiwan Crops and Key Lab of Biopesticide and Chemical Biology, Ministry of Education and College of Plant Protection, Fujian Agriculture and Forestry University, Fuzhou, China.
Yurong WangState Key Laboratory of Ecological Pest Control for Fujian and Taiwan Crops and Key Lab of Biopesticide and Chemical Biology, Ministry of Education and College of Plant Protection, Fujian Agriculture and Forestry University, Fuzhou, China.
Fang CaoState Key Laboratory of Ecological Pest Control for Fujian and Taiwan Crops and Key Lab of Biopesticide and Chemical Biology, Ministry of Education and College of Plant Protection, Fujian Agriculture and Forestry University, Fuzhou, China.
Tianyun ZhaiState Key Laboratory of Ecological Pest Control for Fujian and Taiwan Crops and Key Lab of Biopesticide and Chemical Biology, Ministry of Education and College of Plant Protection, Fujian Agriculture and Forestry University, Fuzhou, China.
Wenhua RaoState Key Laboratory of Ecological Pest Control for Fujian and Taiwan Crops and Key Lab of Biopesticide and Chemical Biology, Ministry of Education and College of Plant Protection, Fujian Agriculture and Forestry University, Fuzhou, China.
Xiong GuanState Key Laboratory of Ecological Pest Control for Fujian and Taiwan Crops and Key Lab of Biopesticide and Chemical Biology, Ministry of Education and College of Plant Protection, Fujian Agriculture and Forestry University, Fuzhou, China.
Lei XuGraduate School of Chinese Academy of Agricultural Sciences, Beijing, China.
Xiaohong PanState Key Laboratory of Ecological Pest Control for Fujian and Taiwan Crops and Key Lab of Biopesticide and Chemical Biology, Ministry of Education and College of Plant Protection, Fujian Agriculture and Forestry University, Fuzhou, China.
Fujian Agriculture and Forestry University · CNChinese Academy of Agricultural Sciences · CN

Funding

No grant is acknowledged in the PubMed record.

6 · The paper itself

Abstract

In this study, a spherical silica nanoparticle was explored as a gatifloxacin carrier synthesized by the chemical precipitation method. It was found that there was no new chemical bond formation during the loading process between gatifloxacin and silica, which implies that the binding was driven by physical interaction. In addition, the drug loading and encapsulation efficiency could be improved by appropriately increasing nano-silica content in the loading process. Meanwhile, the release rate of gatifloxacin after loading nano-silica was also improved, suggesting the successful design of a controlled-release delivery composite. The silica nanocarrier could significantly improve the antibacterial performance of

Indexed as

antibacterial activityE. coligatifloxacinmicroscopic investigationsnano-silica

Identifiers

PMID35096778
PMCPMC8792944
OpenAlexW4205468572

What OpenQuestion holds

Textmetadata
LicenceCC BY
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.