ReviewFrontiers in pediatrics2021
A Review of Febrile Seizures: Recent Advances in Understanding of Febrile Seizure Pathophysiology and Commonly Implicated Viral Triggers.
Review in Frontiers in pediatrics, 2021. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 60 papers, 2 of them syntheses that pooled it.
What it found
Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.
The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.
The trial behind it
Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.
Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.
Who cites it
60 citing papers in PubMed, 2 syntheses or guidelines pooled it, 106 citations in OpenAlex.
- Shining a Light on Trace Elements: A Systematic Review and Meta-analysis of Serum Concentrations in Febrile seizure.Biological trace element research · 2025Pooled it
- The non-clinical burden of febrile seizures: a systematic review.Frontiers in pediatrics · 2024Pooled it
- From discovery through emergency use to the present: Safety evaluation of the COVID-19 mRNA-1273 (Moderna) vaccine.Human vaccines & immunotherapeutics · 2026Review
- CSNK2B-associated epilepsy: family report and literature review.Acta epileptologica · 2026Article
- Distinct clinical clusters of paediatric patients with status epilepticus: Retrospective cohort study.Developmental medicine and child neurology · 2026Article
- cGAS-mediated type I IFN signaling contributes to disease progression in drug-refractory epilepsy.Nature neuroscience · 2026Article
- Can epilepsy be predicted after the first febrile seizure? Insights from machine learning of postictal EEG.Epileptic disorders : international epilepsy journal with videotape · 2026Article
- Integrated Multiomics Reveals Gut-Brain Axis Dysregulation and Phenotype-Specific Metabolic Signatures in Children with Febrile Seizures.Biomedicines · 2026Article
- Oral microbiota characteristics in children younger than 3 years with febrile seizures: a prospective observational study.BMC microbiology · 2026Observational
- Fever seizures beyond the typical age: clinical characteristics and subsequent epilepsy risks in children over five.Acta neurologica Belgica · 2026Review
- Risk Factors Associated With Febrile Seizures in Young Children: Clinical, Biochemical, and Genetic Perspectives.Cureus · 2026Article
- Genetic Polymorphism in Febrile Seizures.Indian journal of pediatrics · 2026Observational
- Breaking the seizure cycle: Belgian expert consensus on the diagnostics and treatment of acute convulsive seizures in children.Acta neurologica Belgica · 2026Review
- Febrile Seizures in an App-Based Children's Fever Registry: Mixed Methods Study.JMIR pediatrics and parenting · 2026Article
- cGAS-mediated IFN-I signaling contributes to disease progression in drug-refractory epilepsy.bioRxiv : the preprint server for biology · 2026Article
- Febrile Seizures in Children in a Low-Resource Setting: A Hospital-Based Cross-Sectional Study from Eastern Libya.Avicenna journal of medicine · 2026Article
- Knowledge and attitude of mother towards home management of febrile seizure in children: A cross-sectional study.SAGE open medicine · 2026Article
- Risk Factors for Initial Febrile Seizures in Pediatric Patients at Iranian Tertiary Hospitals (2019-2021): Retrospective Cross-Sectional Study.Iranian journal of child neurology · 2026Article
- Study of Clinico-Etiological Profile of New-Onset Seizure in Infants.Journal of pharmacy & bioallied sciences · 2025Article
- Beyond the seizure: the role of post-event observation in febrile seizure management.European journal of pediatrics · 2025Review
Corrections and comments
PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.
Authors and funding
3 authors at 3 institutions in 1 country.
Funding
No grant is acknowledged in the PubMed record.
Abstract
Febrile seizures are one of the commonest presentations in young children, with a 2-5% incidence in Western countries. Though they are generally benign, with rare long-term sequelae, there is much to be learned about their pathophysiology and risk factors. Febrile seizures are propagated by a variety of genetic and environmental factors, including viruses and vaccines. These factors must be taken into consideration by a clinician aiming to assess, diagnose and treat a child presenting with fevers and seizures, as well as to explain the sequelae of the febrile seizures to the concerned parents of the child. Our article provides an overview of this common childhood condition, outlining both the underlying mechanisms and the appropriate clinical approach to a child presenting with febrile seizures.
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Registered trials
Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.