Evidence map›Paper›PMID 35096672›Full record

ArticleGerms2021

Association of specific haplotype of tumor necrosis factor-α and interleukin-1β polymorphisms with

Fatemeh Nezamzadeh, Mahboobeh Asadyun, Amir Anbiyaiee, Mansour Sedighi, Abed Zahedi Bialvaei, Younes Khalili, Hamed Ebrahimzadeh Leylabadlo, Aylin Esmailkhani

Open access · greenAbstract read
PubMed Full text at PMC Publisher
In one paragraph

Article in Germs, 2021. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 1 paper.

0numbers the graph read from it
0cells of the map it votes in
1citing papers in PubMed
0.2field-weighted citation impact, top 42% of its field
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

1 citing paper in PubMed, 3 citations in OpenAlex.

  1. Review
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

8 authors at 5 institutions in 1 country.

Fatemeh NezamzadehMD, School of Medicine, Islamic Azad University, Tonekabon Branch, 5 kilometers to Tonekabon City - Vali Abad, Tonekabon, Iran.
Mahboobeh AsadyunMSc, Department of Biology, Science and Research Branch, Islamic Azad University, Shodada Hesarak blvd, Daneshgah Square, Tehran, Iran.
Amir AnbiyaieeMD, Department of Obstetrics & Gynecology, Medical School, Jundishapur University of Medical Sciences, Golestan St., Ahvaz, Iran.
Mansour SedighiPhD, Department of Microbiology, School of Medicine, Iran University of Medical Sciences, Hemmat Highway, next to the Milad Tower, Tehran, Iran.
Abed Zahedi BialvaeiPhD, Microbial Biotechnology Research Center, Iran University of Medical Sciences, Hemmat Highway, next to the Milad Tower, Tehran, Iran.
Younes KhaliliPhD, Department of Microbiology, Faculty of Medicine, Tabriz University of Medical Sciences, Golgasht St., Tabriz, Iran.
Hamed Ebrahimzadeh LeylabadloPhD, Liver and Gastrointestinal Diseases Research Center, Tabriz University of Medical Sciences, Golgasht St., Tabriz, Iran.
Aylin EsmailkhaniMSc, Department of Microbiology, Faculty of Medicine, Tabriz University of Medical Sciences, Golgasht St., Tabriz, Iran.
Tabriz University of Medical Sciences · IRIran University of Medical Sciences · IRAhvaz Jundishapur University of Medical Sciences · IRIslamic Azad University, Science and Research Branch · IRIslamic Azad University Tonekabon · IR

Funding

No grant is acknowledged in the PubMed record.

6 · The paper itself

Abstract

introductionThe

methodsThe polymorphisms of IL-1β and TNF-α genes were analyzed by polymerase chain reaction-restriction fragment length polymorphism (PCR-RFLP) in 290 patients who underwent endoscopy. Infection with

resultsNo significant difference was detected in allele frequency and genotype of all studied polymorphisms between chronic gastritis (CG), GC and healthy individuals. IL-1β mRNA was down-regulated in both gastritis (relative quantification (RQ)=0.447) and the GC groups (RQ=0.151). In contrast, the expression of TNF-α was up-regulated in the GC group (RQ=2.817) compared to the gastritis group (RQ=0.861).

conclusionsThe studied single-nucleotide polymorphisms are not risk factors for development of CG and GC. However,

Indexed as

chronic gastritisGastric cancergene polymorphismsHelicobacter pyloriIL-1βTNF-α

Identifiers

PMID35096672
PMCPMC8789352
OpenAlexW4205193867

What OpenQuestion holds

Textmetadata
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.