ArticleFrontiers in cellular and infection microbiology2021
Association Between Breastmilk Microbiota and Food Allergy in Infants.
Article in Frontiers in cellular and infection microbiology, 2021. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 41 papers, 3 of them syntheses that pooled it.
What it found
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The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.
The trial behind it
Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.
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Who cites it
41 citing papers in PubMed, 3 syntheses or guidelines pooled it, 55 citations in OpenAlex.
- Microbiota Signatures in Early Life and Their Association With Food Allergy: A Systematic Review.Allergy · 2026Pooled it
- Human Milk Bioactive Compounds and Allergic- and Infectious-Related Infant Outcomes: A Systematic Review.Molecular nutrition & food research · 2026Pooled it
- Probiotics and the Potential of Genetic Modification as a Possible Treatment for Food Allergy.Nutrients · 2023Pooled it
- Tryptophan metabolism: A hidden regulator of female reproductive health beyond fertility.Chinese medical journal · 2026Review
- Clinical characteristics, prognosis, and risk factors for tolerance development in food protein-induced allergic proctocolitis: a retrospective cohort study.Translational pediatrics · 2026Article
- Prevalence and indoor environment risk factors of parent-reported food allergy symptoms among preschool children in Haikou City, China: a cross-sectional survey.Frontiers in public health · 2026Article
- Human milk microbiota: origins, determinants, and roles in maternal-infant microbial transmission and infant microbiome assembly.Frontiers in microbiology · 2026Review
- Article
- Functional Foods Based on Postbiotics as a Food Allergy Treatment.Foods (Basel, Switzerland) · 2025Review
- The Association Between Maternal Diet and the Human Milk Microbiome: A Review of Evidence and Methodological Challenges.Microorganisms · 2025Review
- Impact of oral immunotherapy on diversity of gut microbiota in food-allergic children.Pediatric allergy and immunology : official publication of the European Society of Pediatric Allergy and Immunology · 2025Article
- Cow's Milk Allergy in Breastfed Infants: What We Need to Know About Mechanisms, Management, and Maternal Role.Nutrients · 2025Review
- Article
- Effects of post-adulthood environmental hygiene improvement on gut microbiota and immune tolerance in mice.Applied and environmental microbiology · 2025Article
- Neonatal and maternal morbidity rates in low-risk nulliparous women across different gestational ages.iScience · 2025Article
- Prevalence of food allergy and its association with atopic dermatitis in Iran: Results from the PERSIAN birth cohort.The journal of allergy and clinical immunology. Global · 2025Article
- Profiling of the gut, skin and nasal microbiotas revealed clinically relevant microbial taxa from children with allergies: a pilot study.Frontiers in allergy · 2025Article
- Osteocalcin in human breast milk over the course of lactation.Frontiers in endocrinology · 2025Observational
- Immunoglobulin-coating patterns reveal altered humoral responses to gut bacteria in pediatric cow milk allergies.Journal of translational medicine · 2024Article
- Atopic dermatitis and food allergy: More than sensitization.Mucosal immunology · 2024Review
Corrections and comments
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Authors and funding
4 authors at 2 institutions in 1 country.
Funding
No grant is acknowledged in the PubMed record.
Abstract
Regulating the composition of human breastmilk has the potential to prevent allergic diseases early in life. The composition of breastmilk is complex, comprising varying levels of oligosaccharides, immunoactive molecules, vitamins, metabolites, and microbes. Although several studies have examined the relationship between different components of breastmilk and infant food allergies, few have investigated the relationship between microorganisms in breastmilk and infant food allergy. In the present study, we selected 135 healthy pregnant women and their full-term newborns from a cohort of 202 mother-infant pairs. Among them, 69 infants were exclusively breastfed until 6 mo after birth. At follow-up, 11 of the 69 infants developed a food allergy in infancy while 22 showed no signs of allergy. Thirty-three breastmilk samples were collected within 1 mo after delivery, and 123 infant fecal samples were collected at five time points following their birth. These samples were analyzed using microbial 16S rRNA gene sequencing. The abundance and evenness of the milk microbiota and the number of differential bacteria were higher in the breastmilk samples from the non-allergy group than in those from the food allergy group. The non-allergy group showed relatively high abundance of
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Registered trials
Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.