Evidence map›Paper›PMID 35096584›Full record

ArticleFrontiers in oncology2021

Oncological Outcomes After Hippocampus-Sparing Whole-Brain Radiotherapy in Cancer Patients With Newly Diagnosed Brain Oligometastases: A Single-Arm Prospective Observational Cohort Study in Taiwan.

Shinn-Yn Lin, Din-Li Tsan, Chi-Cheng Chuang, Chi-Cheng Yang, Ping-Ching Pai, Chih-Liang Wang, Yi-Ming Wu, Cheng-Chi Lee, Chia-Hsin Lin, Kuo-Chen Wei and 1 more

2 registry-linked trialsOpen access · goldAbstract read
PubMed Full text at PMC Publisher
In one paragraph

Article in Frontiers in oncology, 2021. The graph could read no effect estimate from its abstract, so it casts no vote on the map. It is linked to 2 registered trials, which are not on this map. Cited by 2 papers.

0numbers the graph read from it
0cells of the map it votes in
2citing papers in PubMed
0.5field-weighted citation impact, top 38% of its field
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

NCT02504788 narecruitingnot on this map

A Prospective Study of the Impact of Hippocampal Avoidance During Whole Brain Radiotherapy on Neurocognitive Function Decline

TypeinterventionalSponsorChang Gung Memorial HospitalRan2013 to 2028Enrolled100ConditionsBrain Metastasis, Brain MetastasesArmshippocampal-sparing WBRT
NCT03223675 naunknown statusnot on this map

Neurocognitive Impact and Dose-Effect Relationship of Hippocampal Avoidance During Whole Brain Radiotherapy Plus Simultaneous Integrated Boost - A Prospective Follow-up Study

TypeinterventionalSponsorChang Gung Memorial HospitalRan2016 to 2025Enrolled100ConditionsBrain Metastasis, Brain MetastasesArmshippocampal-sparing WBRT
3 · Its place in the literature

Who cites it

2 citing papers in PubMed, 3 citations in OpenAlex.

  1. Review
  2. Article
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

11 authors at 4 institutions in 1 country.

Shinn-Yn LinDepartment of Radiation Oncology, Chang Gung Memorial Hospital and Chang Gung University, Taoyuan, Taiwan.
Din-Li TsanDepartment of Radiation Oncology, Chang Gung Memorial Hospital and Chang Gung University, Taoyuan, Taiwan.
Chi-Cheng ChuangDepartment of Neurosurgery, Chang Gung Memorial Hospital and Chang Gung University, Taoyuan, Taiwan.
Chi-Cheng YangDepartment of Psychology, National Chengchi University, Taipei, Taiwan.
Ping-Ching PaiDepartment of Radiation Oncology, Chang Gung Memorial Hospital and Chang Gung University, Taoyuan, Taiwan.
Chih-Liang WangCollege of Medicine, Chang Gung University, Taoyuan, Taiwan.
Yi-Ming WuCollege of Medicine, Chang Gung University, Taoyuan, Taiwan.
Cheng-Chi LeeDepartment of Neurosurgery, Chang Gung Memorial Hospital and Chang Gung University, Taoyuan, Taiwan.
Chia-Hsin LinDepartment of Radiation Oncology, Chang Gung Memorial Hospital and Chang Gung University, Taoyuan, Taiwan.
Kuo-Chen WeiDepartment of Neurosurgery, Chang Gung Memorial Hospital and Chang Gung University, Taoyuan, Taiwan.
Wen-Chi ChouCollege of Medicine, Chang Gung University, Taoyuan, Taiwan.
Chang Gung University · TWChang Gung Memorial Hospital · TWNational Chengchi University · TWNational Yang Ming Chiao Tung University · TW

Funding

No grant is acknowledged in the PubMed record.

6 · The paper itself

Abstract

backgroundPromisingly, the technique of hippocampus sparing during WBRT (HS-WBRT) might preserve NCFs. In this research, we examined oncological outcomes, with emphasis on neurologic/non-neurologic causes of death, CNS progression, and leptomeningeal disease (LMD) recurrence in cancer patients who underwent HS-WBRT.

methodsOne hundred and fourteen cancer patients with newly diagnosed brain oligometastases underwent HS-WBRT were consecutively enrolled. The cumulative incidence of cancer-specific deaths (neurologic or non-neurologic), LMD recurrence, and the composite endpoint of CNS progression (CNS-CE) as the first event were computed with a competing-risks approach to characterize the oncological outcomes after HS-WBRT.

resultsPatients with intact brain metastases had a significantly increased likelihood of dying from non-neurologic causes of death associated with early manifestation of progressive systemic disease (hazard ratio for non-neurologic death, 1.78; 95% CI, 1.08-2.95;

conclusionsPatterns of oncological endpoints including neurologic/non-neurologic death and cumulative incidence of CNS progression manifesting as LMD recurrence are clearly clarified and contrasted between patients with intact BMs and those with resection cavities, indicating they are clinically distinct subgroups.

trial registrationClinicalTrials.gov, Identifier: NCT02504788, NCT03223675.

Indexed as

brain oligometastasescompeting riskshippocampus-sparing whole-brain radiotherapyneurologic deathoncological outcomes

Identifiers

PMID35096584
PMCPMC8790705
OpenAlexW4205179346

What OpenQuestion holds

Textmetadata
LicenceCC BY
Read underepoch 390

Registered trials

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.