ArticlePhotoacoustics2022
Nanosecond SRS fiber amplifier for label-free near-infrared photoacoustic microscopy of lipids.
Article in Photoacoustics, 2022. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 17 papers.
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Who cites it
17 citing papers in PubMed.
- Optimization of light source parameters for photoacoustic imaging: trade-offs, technologies, and clinical considerations.JPhys photonics · 2026Review
- Efficient algorithm for optimal wavelength selection in photoacoustic spectral unmixing.Biomedical optics express · 2026Article
- Label-free mid-infrared dichroism-sensitive photoacoustic microscopy for histostructural analysis of engineered heart tissues.Light, science & applications · 2026Article
- A comprehensive review of high-performance photoacoustic microscopy systems.Photoacoustics · 2025Review
- Multi-spectral optoacoustic microscopy driven by gas-filled hollow-core fiber laser pulses.Biomedical optics express · 2025Article
- High spectral energy density all-fiber nanosecond pulsed 1.7 μm light source for photoacoustic microscopy.Photoacoustics · 2025Article
- Review on Multispectral Photoacoustic Imaging Using Stimulated Raman Scattering Light Sources.Sensors (Basel, Switzerland) · 2025Review
- Label-free optical microscopy with artificial intelligence: a new paradigm in pathology.Biophotonics discovery · 2025Review
- Photoacoustic imaging of rat kidney tissue oxygenation using second near-infrared wavelengths.Journal of biomedical optics · 2025Article
- Mid-infrared photoacoustic brain imaging enabled by cascaded gas-filled hollow-core fiber lasers.Neurophotonics · 2024Article
- Electronically Controlled Dual-Wavelength Switchable SRS Fiber Amplifier in the NIR-II Region for Multispectral Photoacoustic Microscopy.Laser & photonics reviews · 2024Article
- Photoacoustic imaging plus X: a review.Journal of biomedical optics · 2024Review
- Visualization of Microcirculation at Acupoints in vivo of Alzheimer's Disease Animal Model with Photoacoustic Microscope: A Pilot Study.Journal of Alzheimer's disease reports · 2024Article
- Photoacoustic imaging on its way toward clinical utility: a tutorial review focusing on practical application in medicine.Journal of biomedical optics · 2023Review
- Azimuth mapping of fibrous tissue in linear dichroism-sensitive photoacoustic microscopy.Photoacoustics · 2023Article
- Efficient label-freePhotoacoustics · 2023Article
- Two-step proximal gradient descent algorithm for photoacoustic signal unmixing.Photoacoustics · 2022Article
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6 authors.
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Abstract
Near-infrared photoacoustics receives increasing interest as an intravital modality to sense key biomolecules. One of the most central types of biomolecules of interest are lipids as they constitute essential bio-hallmarks of cardiovascular and metabolic diseases and their in-vivo detection holds insightful information about disease progression and treatment monitoring. However, the full potential of near-infrared photoacoustic for high-resolution and high-sensitivity biomedical studies of lipids has so far not been exploited due a lack of appropriate excitation sources delivering short-pulses at high-repetition-rate, high-pulse-energy, and wavelength around 1200 nm. Here, we demonstrate a custom-built SRS fiber amplifier that provides optical excitations at 1192.8 nm, repetition rates of 200 kHz, pulse durations below 2 ns, and pulse energies beyond 5 μJ. We capitalize on the performance of our excitation source and show near-infrared photoacoustics resolving intrinsic lipid contrast in biomedically relevant specimens ranging from single cells to lipid-rich tissue with subcellular resolution.
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