Evidence map›Paper›PMID 35096420›Full record

ArticleJournal of systems and integrative neuroscience2020

Induction of homeostatic biological parameters in reward deficiency as a function of an iron-free multi-nutrient complex: Promoting hemoglobinization, aerobic metabolism, viral immuno-competence, and neuroinflammatory regulation.

Kenneth Blum, Bernard W Downs, Manashi Bagchi, Steve Kushner, Bruce S Morrison, Jeffrey Galvin, Kourtney Randsdorp, Justin Randsdorp, Rajendra D Badgaiyan, Eric R Braverman and 1 more

Open access · diamondAbstract read
In one paragraph

Article in Journal of systems and integrative neuroscience, 2020. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Not yet cited in PubMed.

0numbers the graph read from it
0cells of the map it votes in
0citing papers in PubMed
0.2field-weighted citation impact, top 59% of its field
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

0 citing papers in PubMed, 3 citations in OpenAlex.

No citing paper in PubMed yet.

4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

11 authors at 7 institutions in 1 country.

Kenneth BlumGraduate College, Western University, Health Sciences, Pomona, CA, USA.
Bernard W DownsVictory Nutrition International, Inc., Department of R&D, Lederach, PA USA.
Manashi BagchiDr. Herbs LLC, R&D, Concord, CA USA.
Steve KushnerALM R&D, Oldsmar, FL USA.
Bruce S MorrisonMorrison Family and Sports Medicine, Huntingdon Valley, PA USA.
Jeffrey GalvinVitality Medical Wellness Institute, PLLC, Charlotte, NC USA.
Kourtney RandsdorpFunctional Freedom LLC, Lancaster, PA, USA.
Justin RandsdorpFunctional Freedom LLC, Lancaster, PA, USA.
Rajendra D BadgaiyanDepartment of Psychiatry, ICHAN School of Medicine, Mount Sinai, New York, NY, USA.
Eric R BravermanPath Foundation NY, New York, NY, USA.
Debasis BagchiVictory Nutrition International, Inc., Department of R&D, Lederach, PA USA.
Freedom House · USCritical Path Institute · USh2med (United States) · USTexas Medical Center · USUniversity of Houston · USVitality Institute · USWestern University of Health Sciences · US

Funding

CSRD VA I01 CX000479
6 · The paper itself

Abstract

backgroundA common neurological condition worldwide is Reward Deficiency Syndrome (RDS) leading to both substance and non-substance addictive behaviors, that must be combatted by integrating both central nervous system and peripheral nervous system biological approaches. Integrity of hemoglobin is a crucial determining factor for the overall health functions. Nutrient repletion therapy should be a fundamental strategy to restore the healthy properties of blood. A unique patent-pending iron-free VMP35 formulation was engineered by our laboratory to restore iron-dependent hemoglobin in anemic cells using a proprietary Prodosome

methodsThe efficacy of the novel therapeutic iron-free VMP35 liquid nutraceutical is detailed in restoring iron-dependent hemoglobin to RBCs and boosting cellular morphology, viability, and immune competence, thereby reducing the need for prolonging inflammatory sequela.

resultsThis was demonstrated in a previous IRB approved multi-subject human study. In addition, two recent case studies report dramatic restorative benefits of nutrient repletion therapy of the VMP35 on subjects having experienced near-fatal events, which confirmed the findings explained in this manuscript.

conclusionsThis novel iron-free VMP35 modulates an array of homeostatic biological parameters such as enhanced hemoglobinization, aerobic metabolism, viral immuno-competence, and inflammatory regulation. Further research, examining mechanistic and beneficial effects in athletic performance, is in progress. Importantly, during these troubled immune challenging times, modulating an array of homeostatic immunological and inflammatory dysfunctions are tantamount to improved population outcomes.

trial registrationThe Clinical investigation in a total of 38 subjects was conducted under an Institutional Review Board (IRB) from the Path Foundation in New York, NY (#13-009 April 25, 2013). The two case studies were done at Lancaster General Hospital, Lancaster, PA, and Jefferson University Hospital, Philadelphia, PA, USA. Both studies were retrospectively registered.

Indexed as

aerobic metabolismanaerobic metabolismblood hemoglobinizationchronic anemia syndromehypoxiaimmunityinflammationneutrophilsred blood cellsreductionist paradigmsystems biologyviral insultVMP35

Identifiers

PMID35096420
PMCPMC8793786
OpenAlexW4210523958

What OpenQuestion holds

Textmetadata
LicenceCC BY
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.