ReviewNeuro-oncology practice2022
Missing repeated measures data in clinical trials.
Review in Neuro-oncology practice, 2022. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 21 papers.
What it found
Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.
The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.
The trial behind it
Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.
Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.
Who cites it
21 citing papers in PubMed.
- Effects of six weeks of guanidinoacetic acid supplementation with and without creatine monohydrate on cognitive function and markers of health in healthy adults.Journal of the International Society of Sports Nutrition · 2026Trial
- Efficacy of Human Milk Oligosaccharide 6'-Sialyllactose Supplementation on Exercise Performance and Training Adaptations.Nutrients · 2026Trial
- Addressing Mental Health Symptoms Among COVID-19 Healthcare Workers: A Heart Rate Variability Biofeedback Pilot Study.Stress and health : journal of the International Society for the Investigation of Stress · 2024Trial
- Are we reporting well enough? A systematic survey of missing data in patient-reported outcomes from non-small cell lung cancer randomized trials.Health and quality of life outcomes · 2026Article
- The effects of cluster-set resistance training on mental health and sleep quality in sedentary young women: protocol for a randomized controlled trial.Frontiers in psychology · 2026Article
- MMPro-HIP: multimodal progressive fusion model for elderly HIP fracture risk prediction.Frontiers in medicine · 2026Article
- Red blood cell distribution width-to-albumin ratio and in-hospital major adverse cardiovascular events in patients with acute myocardial infarction complicated by cardiogenic shock: a two-center retrospective cohort study.Frontiers in cardiovascular medicine · 2026Article
- Nociception and pain assessment during suctioning procedures in mechanically ventilated patients in the intensive care unit: A validation study of the Nociception Level index (NOL™).Canadian journal of pain = Revue canadienne de la douleur · 2026Article
- The impact of a patient navigator on readiness assessment scores in youth transitioning to adult health care in Alberta.Health care transitions · 2026Article
- Article
- Best practices and pragmatic approaches for patient-reported outcomes and quality of life measures in cancer clinical trials.Journal of the National Cancer Institute. Monographs · 2025Article
- Challenges to and considerations of designing cancer prevention trials.Journal of the National Cancer Institute. Monographs · 2025Article
- Caregivers influence preferred place of death for patients with an advanced cancer.Palliative & supportive care · 2025Article
- Development and validation of a diagnostic model for migraine without aura in inpatients.Frontiers in neurology · 2025Article
- An integrated multifocal tDCS-EEG protocol for reducing cognitive and affective symptoms in mild cognitive impairment and early stages of dementia: a crossover double-blind randomized controlled trial.Frontiers in neurology · 2025Article
- An Online Single-Session Cognitive Behavioral Therapy for Depression and Anxiety Associated with Multiple Sclerosis-Pilot Study.Behavioral sciences (Basel, Switzerland) · 2024Article
- One minute of stair climbing and descending reduces postprandial insulin and glucose with 3-min improving insulin resistance following a mixed meal in young adults: A Randomized Controlled Crossover Trial.Journal of exercise science and fitness · 2024Article
- Quantifying bias due to missing data in quality of life surveys of advanced-stage cancer patients.Quality of life research : an international journal of quality of life aspects of treatment, care and rehabilitation · 2024Article
- Risk of bias assessment tool for systematic review and meta-analysis of the gut microbiome.Gut microbiome (Cambridge, England) · 2023Article
- The standards of reporting trials in pets (PetSORT): Explanation and elaboration.Frontiers in veterinary science · 2023Article
Corrections and comments
PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.
Authors and funding
3 authors.
Funding
Abstract
Clinical trials typically collect longitudinal data, data that are collected repeated over time, such as laboratories, scans, or patient-reported outcomes. Due to a variety of reasons, this data can be missing, whether a patient stops attending clinical visits (ie, dropout) or misses assessments intermittently. Understanding the reasons for missing data as well as predictors of missing data can aid in determination of the missing data mechanism. The analysis methods used are dependent on the missing data mechanism and may make certain assumptions about the missing data itself. Methods for nonignorable missing data, which assumes that the missing data depend on the missing data itself, make stronger assumptions and include pattern-mixture models and shared parameter models. Missing data that are ignorable after adjusting for other covariates can be analyzed using methods that adjust for covariates, such as mixed-effects models or multiple imputation. Missing data that are ignorable can be analyzed using standard approaches that require complete case data, such as change from baseline or proportion of patients who declined at a specified time point. In clinical trials, truly ignorable data are rare, resulting in additional analysis methods required for proper interpretation of the results. Conducting several analyses under different assumptions, called sensitivity analyses, can determine the extent of the impact of the missing data.
Indexed as
Identifiers
What OpenQuestion holds
Registered trials
Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.