Evidence map›Paper›PMID 35096334›Full record

ArticleArchives of Razi Institute2021

Investigation of Taurine Derivative Magnesium-Bis-(2-Aminoethanesulfonic)-Butadioateon Alleviation of Neurological Defects in Simulated Hemorrhagic Stroke in Rats.

N I Nesterova, E A Patrakhanov, V V Pokrovskii, I V Pirozhkov, T G Pokrovskaya, N B Levit, M I Ivanova, S N M Kizi, A V Nesterov, V I Shutov and 1 more

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Article in Archives of Razi Institute, 2021. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Not yet cited in PubMed.

0numbers the graph read from it
0cells of the map it votes in
0citing papers in PubMed
–field-weighted citation impact
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

0 citing papers in PubMed.

No citing paper in PubMed yet.

4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

11 authors.

N I NesterovaRegional State Funded Healthcare Facility "Belgorod Forensic Medical Bureau", 159, Volchanskaya St., Belgorod, 308017, Russia.
E A PatrakhanovBelgorod State National Research University, 85, Pobeda St., Belgorod, 308015, Russia.
V V PokrovskiiBelgorod State National Research University, 85, Pobeda St., Belgorod, 308015, Russia.
I V PirozhkovRegional State Funded Healthcare Facility "Belgorod Forensic Medical Bureau", 159, Volchanskaya St., Belgorod, 308017, Russia.
T G PokrovskayaBelgorod State National Research University, 85, Pobeda St., Belgorod, 308015, Russia.
N B LevitRegional State Funded Healthcare Facility "Belgorod Forensic Medical Bureau", 159, Volchanskaya St., Belgorod, 308017, Russia.
M I IvanovaBelgorod State National Research University, 85, Pobeda St., Belgorod, 308015, Russia.
S N M KiziBelgorod State National Research University, 85, Pobeda St., Belgorod, 308015, Russia.
A V NesterovRegional State Funded Healthcare Facility "Belgorod Forensic Medical Bureau", 159, Volchanskaya St., Belgorod, 308017, Russia.
V I ShutovBelgorod Regional Hospital of St. Joasaph, 8/9, Nekrasova St., Belgorod, 308036, Russia.
Y A HoshchenkoBelgorod State National Research University, 85, Pobeda St., Belgorod, 308015, Russia.

Funding

No grant is acknowledged in the PubMed record.

6 · The paper itself

Abstract

Stroke or ischemia is caused by a blockage in a specific blood vessel that partially or completely reduces the blood flow to the brain. Nutritional factors such as antioxidants and healthy eating patterns are important variables in preventing stroke. Molecular composition properties such as molecular binding and screening can be used to evaluate the specific activity and morphological changes. The present study aimed to evaluate the effectiveness of pharmacological correction of the consequences of a hemorrhagic stroke in rats with a new derivative of taurine magnesium-bis-(2-aminoethanesulfonic)-butadioate. The animals (n=170) were divided into four groups as follows: 1) control group (n=20), 2) group 2 suffered a hemorrhagic stroke without pharmacological correction (n=50), 3) group 3 (n=50) underwent simulation of hemorrhagic stroke received Taurine at the dose of 50 mg/kg, 4) Group 4 underwent simulation of hemorrhagic stroke with correction of hemorrhagic stroke with magnesium-bis-(2-aminoethanesulfonic)-butadioate at the dose of 150 mg/kg (LKHT 3-17) (n=50). Hemorrhagic stroke was induced by transfusing autologous blood into the parietal lobe of the right hemisphere of the brain. Lethality, neurological status, locomotor, and exploratory behavior, as well as the morphological pattern of the brain damage, were assessed on the 1

Indexed as

Hemorrhagic StrokeStrokeAnimalsAntioxidantsMagnesiumRatsTaurineAntioxidantsMagnesiumTaurineHemorrhagic strokeNeuroprotectionTaurine

Identifiers

PMID35096334
PMCPMC8790990

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Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.