Evidence map›Paper›PMID 35096258›Full record

ArticleThe Journal of clinical and aesthetic dermatology2021

Serum Neurotensin: An Objective Mirror to Acne-induced Quality of Life and Psychological Impairment.

Nancy W Mikhael, Amira I Mansour, Esraa M Salah El Din, Mohammed Hammad El Azab, Rehab M Salem

Open access · greenAbstract read
PubMed Full text at PMC
In one paragraph

Article in The Journal of clinical and aesthetic dermatology, 2021. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 3 papers.

0numbers the graph read from it
0cells of the map it votes in
3citing papers in PubMed
0.4field-weighted citation impact, top 30% of its field
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

3 citing papers in PubMed, 2 citations in OpenAlex.

  1. Review
  2. Review
  3. Anxiety and Depression: What Do We Know of Neuropeptides?Behavioral sciences (Basel, Switzerland) · 2022
    Review
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

5 authors at 1 institution in 1 country.

Nancy W MikhaelDr. Mikhael is a Professor of Dermatology and Andrology and Dr. Salem is an Assistant Professor of Dermatology and Andrology, Dermatology Department, Faculty of Medicine, at Benha University in Benha, Egypt.
Amira I MansourDr. Mikhael is a Professor of Dermatology and Andrology and Dr. Salem is an Assistant Professor of Dermatology and Andrology, Dermatology Department, Faculty of Medicine, at Benha University in Benha, Egypt.
Esraa M Salah El DinDr. Mikhael is a Professor of Dermatology and Andrology and Dr. Salem is an Assistant Professor of Dermatology and Andrology, Dermatology Department, Faculty of Medicine, at Benha University in Benha, Egypt.
Mohammed Hammad El AzabDr. Mikhael is a Professor of Dermatology and Andrology and Dr. Salem is an Assistant Professor of Dermatology and Andrology, Dermatology Department, Faculty of Medicine, at Benha University in Benha, Egypt.
Rehab M SalemDr. Mikhael is a Professor of Dermatology and Andrology and Dr. Salem is an Assistant Professor of Dermatology and Andrology, Dermatology Department, Faculty of Medicine, at Benha University in Benha, Egypt.
Benha University · EG

Funding

No grant is acknowledged in the PubMed record.

6 · The paper itself

Abstract

backgroundAcne is a multifactorial disorder, and stress potentially plays a role in its pathogenesis.

objectivesWe aimed to assess the serum levels of neurotensin in patients with acne vulgaris (AV) and investigate the relationship of these levels to quality of life (QoL), depression, anxiety, and stress.

methodsThe study included 60 patients with AV classified into mild (n=20), moderate (n=20), and severe (n=20) groups and 20 healthy, age-matched, sex-matched, and body mass index (BMI)-matched individuals in a control group. Patient QoL was assessed using the Dermatology Life Quality Index (DLQI). Each participant completed the Hospital Anxiety and Depression Scale (HADS) and Perceived Stress Scale (PSS-10). Serum levels of neurotensin were measured with enzyme-linked immunosorbent assay (ELISA).

resultsNeurotensin levels and scores from the three questionnaires were significantly higher among the patients with AV than the control subjects. They were also significantly elevated in patients with post-acne scars and hyperpigmentation and in those with severe acne.

conclusionIt is well known that acne greatly impacts QoL and might be associated with depression, anxiety, and stress. Further, serum neurotensin could be a promising marker to objectively evaluate the psychosocial impact of AV.

Indexed as

Acneanxietydepressionneurotensinquality of life

Identifiers

PMID35096258
PMCPMC8794489
OpenAlexW4210821674

What OpenQuestion holds

Textmetadata
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.