Evidence map›Paper›PMID 35096137›Full record

ArticleComputational and mathematical methods in medicine2022

miR-124a Involves in the Regulation of Wnt/

Yunhui Li, Meifeng Lv, Mingshu Lu, Hongliang Guan

RetractedOpen access · hybridAbstract readRetracted Publication
PubMed Full text at PMC Publisher
In one paragraph

Article in Computational and mathematical methods in medicine, 2022. The graph could read no effect estimate from its abstract, so it casts no vote on the map. It has been retracted, and should not be counted. Cited by 5 papers.

0numbers the graph read from it
0cells of the map it votes in
5citing papers in PubMed
0.8field-weighted citation impact, top 30% of its field
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

5 citing papers in PubMed, 5 citations in OpenAlex.

  1. Review
  2. Novel pharmacological approaches in abdominal aortic aneurysm.Clinical science (London, England : 1979) · 2023
    Review
  3. Review
  4. Retracted: miR-124a Involves in the Regulation of Wnt/Computational and mathematical methods in medicine · 2023
    Article
  5. Article
4 · The record

Corrections and comments

  • Retraction · 2023-07-19Concerns/Issues about Data · Concerns/Issues about Human Subject Welfare · Concerns/Issues about Referencing/Attributions · Concerns/Issues about Peer Review · Investigation by Journal/Publisher · Investigation by Third Party · Lack of IRB/IACUC Approval and/or Compliance · Unreliable Results and/or Conclusions ·
  • Retracted
5 · Who and what money

Authors and funding

4 authors at 3 institutions in 1 country.

Yunhui LiDepartment of Vascular Surgery, Jinan People's Hospital Affiliated to Shandong First Medical University, China.
Meifeng LvPharmacy Department of Jinan Second Maternal and Child Health Hospital, China.
Mingshu LuDepartment of Vascular Surgery, Jinan People's Hospital Affiliated to Shandong First Medical University, China.
Hongliang GuanDepartment of Vascular Surgery, Shandong Shanxian Central Hospital, China.ORCID https://orcid.org/0000-0001-7222-5944
Jinan City People's Hospital · CNShandong Maternal and Child Health Hospital · CNXian Central Hospital · CN

Funding

No grant is acknowledged in the PubMed record.

6 · The paper itself

Abstract

backgroundAbdominal aortic aneurysm (AAA) belongs to a progressive, gradual aortic rupture, which can lead to death without surgical intervention. The key factors regulating the occurrence and progress of AAA are not clear. Increasing studies have indicated that microRNA (miRNA) plays an important role in cancer development. miR-124a serves as a tumor suppressor in several neoplasms, and its upregulation can greatly inhibit the life activities such as malignant growth and migration of tumor cells.

aimThe objective of this study is to explore the association of miR-124a with AAA and to uncover the regulated mechanism of miR-124a on AAA progression.

methodsThe specimens from the AAA patients were used for observing the miR-124a expression, and human aortic endothelial cells (hAoECs) were treated with AngII to establish the AAA cell models. The quantitative reverse transcriptase-polymerase chain reaction (qRT-PCR), CCK-8, transwell assay, flow cytometry assay, and western blot were conducted to unearth the regulation mechanism of miR-124a on AAA, and the dual-luciferase reporter assay was employed to investigate the downstream target of miR-124a.

resultsmiR-124a was significantly downregulated in the whole blood of the patients, and the decreased miR-124a was also observed in AAA cell models. Overexpressing miR-124a could effectively inhibit the proliferation and migration and promote the apoptosis of the AAA cells. The dual-luciferase reporter assay confirmed that BRD4 was a downstream target of miR-124a, and BRD4 upregulation could obviously reverse the effects of miR-124a on the phenotype of AAA cells. Moreover, it was found that miR-124a could regulate the activities of Wnt/

conclusionOur data suggested that miR-124a could regulate the activities of Wnt/

Indexed as

Wnt Signaling PathwayAortic Aneurysm, Abdominalbeta CateninBromodomain Containing ProteinsCell Cycle ProteinsCell MovementCell ProliferationCells, CulturedComputational BiologyDisease ProgressionDown-RegulationEndothelial CellsGene Expression RegulationGenes, Tumor SuppressorHumansMicroRNAsbeta CateninBRD4 protein, humanBromodomain Containing ProteinsCell Cycle ProteinsCTNNB1 protein, humanMicroRNAsMIRN124 microRNA, humanTP53 protein, humanTranscription FactorsTumor Suppressor Protein p53

Identifiers

PMID35096137
PMCPMC8799344
OpenAlexW4206047538

What OpenQuestion holds

Textmetadata
LicenceCC BY
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.