Evidence map›Paper›PMID 35095910›Full record

ReviewFrontiers in immunology2021

Anti-Inflammatory Effects of Acupuncture at ST36 Point: A Literature Review in Animal Studies.

Ji-Eun Oh, Seung-Nam Kim

Registry-linked trialOpen access · goldAbstract readReview
PubMed Full text at PMC Publisher
In one paragraph

Review in Frontiers in immunology, 2021. The graph could read no effect estimate from its abstract, so it casts no vote on the map. It is linked to trial NCT07185854 (Acupuncture Combined With Artificial Tears Compared With Artificial Tears Alone in Moderate Dry Eye), which is not on this map. Cited by 104 papers, 17 of them syntheses that pooled it.

0numbers the graph read from it
0cells of the map it votes in
104citing papers in PubMed, 17 pooled it
44.7field-weighted citation impact, top 1% of its field
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

NCT07185854 nacompletednot on this mapstarted 2024, after this paper: background citation

Acupuncture Combined With Artificial Tears Compared With Artificial Tears Alone in Moderate Dry Eye: A Randomized Controlled Trial

TypeinterventionalSponsorNadide KocaRan2024 to 2025Enrolled90ConditionsDry Eye, AcupunctureArmsArtificial tears, Traditional Chinese Medicine Acupuncture
3 · Its place in the literature

Who cites it

104 citing papers in PubMed, 17 syntheses or guidelines pooled it, 159 citations in OpenAlex.

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  3. Efficacy of acupuncture in managing radiotherapy/chemotherapy-induced oral mucositis: a systematic review and meta-analysis.Supportive care in cancer : official journal of the Multinational Association of Supportive Care in Cancer · 2025
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44 more citing papers are in PubMed but not listed here.

4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

2 authors at 1 institution in 1 country.

Ji-Eun OhCollege of Korean Medicine, Dongguk University, Goyang, South Korea.
Seung-Nam KimCollege of Korean Medicine, Dongguk University, Goyang, South Korea.
Dongguk University · KR

Funding

No grant is acknowledged in the PubMed record.

6 · The paper itself

Abstract

So far, a number of acupuncture studies have shown anti-inflammatory effects of acupuncture treatment, mostly known at specific point ST36. However, there is no literature that oversaw the inflammation-regulatory effects of acupuncture in each tissue. Therefore, we investigated how acupuncture at specific acupoint ST36 regulates inflammation and its underlying mechanisms. We searched literatures on PubMed until July 2021 using the keywords "animal, acupuncture, ST36, inflammation, immune," and 292 literatures were searched. We ultimately selected 69 studies to determine the anti-inflammatory actions of acupuncture at ST36 and classified the changes of inflammatory mediators according to target regions. Forty-three studies were included in body fluids, 27 studies in the digestive system, 17 studies in the nervous system, and 30 studies in other tissues or organs. In this review, we found that acupuncture at ST36 has clinical benefits in relieving inflammation through several mechanisms such as vagus nerve activation, toll-like receptor 4 (TLR4)/NF-κB signaling, macrophage polarization, mitogen-activated protein kinase (MAPK) signaling pathway, and cholinergic anti-inflammatory pathway. We expect that these data will inform further studies related to ST36 acupuncture on inflammation.

Indexed as

AcupunctureAcupuncture PointsAcupuncture TherapyAnimalsBiomarkersDisease Models, AnimalGene Expression RegulationImmunomodulationInflammationInflammation MediatorsNeuroimmunomodulationSignal TransductionTreatment OutcomeBiomarkersInflammation Mediatorsacupoint ST36acupunctureanimal studyanti-inflammatory effectsliterature review

Identifiers

PMID35095910
PMCPMC8790576
OpenAlexW4206066092

What OpenQuestion holds

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Registered trials

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.