Evidence map›Paper›PMID 35095862›Full record

ArticleFrontiers in immunology2021

Anti-CD40 Antibody Fused to CD40 Ligand Is a Superagonist Platform for Adjuvant Intrinsic DC-Targeting Vaccines.

Valentina Ceglia, Sandra Zurawski, Monica Montes, Mitchell Kroll, Aurélie Bouteau, Zhiqing Wang, Jerome Ellis, Botond Z Igyártó, Yves Lévy, Gerard Zurawski

Open access · goldAbstract read
In one paragraph

Article in Frontiers in immunology, 2021. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 14 papers.

0numbers the graph read from it
0cells of the map it votes in
14citing papers in PubMed
1.9field-weighted citation impact, top 14% of its field
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

14 citing papers in PubMed, 23 citations in OpenAlex.

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  14. FcγRs and Their Relevance for the Activity of Anti-CD40 Antibodies.International journal of molecular sciences · 2022
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4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

10 authors at 6 institutions in 2 countries.

Valentina CegliaBaylor Scott and White Research Institute, Dallas, TX, United States.
Sandra ZurawskiBaylor Scott and White Research Institute, Dallas, TX, United States.
Monica MontesBaylor Scott and White Research Institute, Dallas, TX, United States.
Mitchell KrollBaylor Scott and White Research Institute, Dallas, TX, United States.
Aurélie BouteauInstitute of Biomedical Studies, Baylor University, Waco, TX, United States.
Zhiqing WangBaylor Scott and White Research Institute, Dallas, TX, United States.
Jerome EllisBaylor Scott and White Research Institute, Dallas, TX, United States.
Botond Z IgyártóBaylor Scott and White Research Institute, Dallas, TX, United States.
Yves LévyUniversité Paris-Est Créteil, Sciences de la Vie et de la Santé, Créteil, France.
Gerard ZurawskiBaylor Scott and White Research Institute, Dallas, TX, United States.
Research Institute of Dallas · USBaylor University · USInserm · FRBaylor Medical Center at Garland · USInstitut de Recherche Vaccinale · FRInstitut Mondor de Recherche Biomédicale · FR

Funding

DC-subset-tailored vaccinesR01AI146420 · NIAID · THOMAS JEFFERSON UNIVERSITY · PI IGYARTO, BOTOND Z · 2020 to 2024
$1.9M
NIAID NIH HHS R01 AI146420
6 · The paper itself

Abstract

CD40 is a potent activating receptor expressed on antigen-presenting cells (APCs) of the immune system. CD40 regulates many aspects of B and T cell immunity

Indexed as

Adjuvants, ImmunologicAdjuvants, VaccineAnimalsAntibodiesCD40 AntigensCD40 LigandCD4-Positive T-LymphocytesCD8-Positive T-LymphocytesCells, CulturedDendritic Cellsenv Gene Products, Human Immunodeficiency VirusFemaleHIV-1HumansImmunity, CellularImmunity, HumoralAdjuvants, ImmunologicAdjuvants, VaccineAntibodiesCD40 AntigensCD40 Ligandenv Gene Products, Human Immunodeficiency Virusgp140 envelope protein, Human immunodeficiency virus 1Vaccinesadjuvant-intrinsicdendritic cellsmonoclonal antibodiessuperagonistvaccine

Identifiers

PMID35095862
PMCPMC8792972
OpenAlexW4205135146

What OpenQuestion holds

Textmetadata
LicenceCC BY
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.