Evidence map›Paper›PMID 35095852›Full record

ArticleFrontiers in immunology2021

TRPM2 Is Not Required for T-Cell Activation and Differentiation.

Niels C Lory, Mikolaj Nawrocki, Martina Corazza, Joanna Schmid, Valéa Schumacher, Tanja Bedke, Stephan Menzel, Friedrich Koch-Nolte, Andreas H Guse, Samuel Huber and 1 more

Open access · goldAbstract read
In one paragraph

Article in Frontiers in immunology, 2021. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 7 papers.

0numbers the graph read from it
0cells of the map it votes in
7citing papers in PubMed
0.8field-weighted citation impact, top 36% of its field
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

7 citing papers in PubMed, 6 citations in OpenAlex.

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  3. Controversy and multiple roles of the solitary nucleus receptor Nur77 in disease and physiology.FASEB journal : official publication of the Federation of American Societies for Experimental Biology · 2025
    Review
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4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

11 authors at 2 institutions in 1 country.

Niels C LoryDepartment for Immunology, University Medical Center Hamburg-Eppendorf, Hamburg, Germany.
Mikolaj NawrockiHamburg Center for Translational Immunology (HCTI), University Medical Center Hamburg-Eppendorf, Hamburg, Germany.
Martina CorazzaHamburg Center for Translational Immunology (HCTI), University Medical Center Hamburg-Eppendorf, Hamburg, Germany.
Joanna SchmidDepartment for Immunology, University Medical Center Hamburg-Eppendorf, Hamburg, Germany.
Valéa SchumacherDepartment for Immunology, University Medical Center Hamburg-Eppendorf, Hamburg, Germany.
Tanja BedkeHamburg Center for Translational Immunology (HCTI), University Medical Center Hamburg-Eppendorf, Hamburg, Germany.
Stephan MenzelDepartment for Immunology, University Medical Center Hamburg-Eppendorf, Hamburg, Germany.
Friedrich Koch-NolteDepartment for Immunology, University Medical Center Hamburg-Eppendorf, Hamburg, Germany.
Andreas H GuseMildred Scheel Cancer Career Center HaTriCS4, University Medical Center Hamburg-Eppendorf, Hamburg, Germany.
Samuel HuberHamburg Center for Translational Immunology (HCTI), University Medical Center Hamburg-Eppendorf, Hamburg, Germany.
Hans-Willi MittrückerDepartment for Immunology, University Medical Center Hamburg-Eppendorf, Hamburg, Germany.
Universität Hamburg · DEUniversity Medical Center Hamburg-Eppendorf · DE

Funding

No grant is acknowledged in the PubMed record.

6 · The paper itself

Abstract

Antigen recognition by the T-cell receptor induces a cytosolic Ca

Indexed as

AnimalsCalcium SignalingCD4-Positive T-LymphocytesCD8-Positive T-LymphocytesCell DifferentiationCell ProliferationListeria monocytogenesListeriosisLymphocyte ActivationMiceMice, Inbred C57BLTh17 CellsTh1 CellsT-Lymphocytes, RegulatoryTRPM Cation ChannelsTRPM2 protein, mouseTRPM Cation ChannelsADPRcalcium signalingT-cell activationT cellsTCR signalingTRPM2

Identifiers

PMID35095852
PMCPMC8795911
OpenAlexW4206532824

What OpenQuestion holds

Textmetadata
LicenceCC BY
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.