Evidence map›Paper›PMID 35095849›Full record

ArticleFrontiers in immunology2021

STING Signaling Drives Production of Innate Cytokines, Generation of CD8

Raquel de Souza Vieira, Marilda Savoia Nascimento, Isaú Henrique Noronha, José Ronnie Carvalho Vasconcelos, Luiz Alberto Benvenuti, Glen N Barber, Niels Olsen Saraiva Câmara, Jorge Kalil, Edecio Cunha-Neto, Rafael Ribeiro Almeida

Open access · goldAbstract read
In one paragraph

Article in Frontiers in immunology, 2021. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 10 papers.

0numbers the graph read from it
0cells of the map it votes in
10citing papers in PubMed
2.2field-weighted citation impact, top 13% of its field
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

10 citing papers in PubMed, 14 citations in OpenAlex.

  1. Bugs as drugs: parasite biomolecules as novel therapeutics against breast cancer.American journal of physiology. Cell physiology · 2026
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4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

10 authors at 5 institutions in 2 countries.

Raquel de Souza VieiraLaboratório de Imunologia, Instituto do Coração, Faculdade de Medicina da Universidade de São Paulo, São Paulo, Brazil.
Marilda Savoia NascimentoLaboratório de Imunologia, Instituto do Coração, Faculdade de Medicina da Universidade de São Paulo, São Paulo, Brazil.
Isaú Henrique NoronhaLaboratório de Vacinas Recombinantes, Departamento de Biociências, Universidade Federal de São Paulo, Santos, Brazil.
José Ronnie Carvalho VasconcelosLaboratório de Vacinas Recombinantes, Departamento de Biociências, Universidade Federal de São Paulo, Santos, Brazil.
Luiz Alberto BenvenutiDivisão de Patologia, Instituto do Coração (INCOR), Faculdade de Medicina, Universidade de São Paulo, São Paulo, Brazil.
Glen N BarberDepartment of Cell Biology, University of Miami, Miami, FL, United States.
Niels Olsen Saraiva CâmaraLaboratório de Imunologia Experimental e Clínica, Departamento de Clínica Médica, Faculdade de Medicina, Universidade Federal de São Paulo, São Paulo, Brazil.
Jorge KalilLaboratório de Imunologia, Instituto do Coração, Faculdade de Medicina da Universidade de São Paulo, São Paulo, Brazil.
Edecio Cunha-NetoLaboratório de Imunologia, Instituto do Coração, Faculdade de Medicina da Universidade de São Paulo, São Paulo, Brazil.
Rafael Ribeiro AlmeidaLaboratório de Imunologia, Instituto do Coração, Faculdade de Medicina da Universidade de São Paulo, São Paulo, Brazil.
Hospital das Clínicas da Faculdade de Medicina da Universidade de São Paulo · BRInstituto Nacional de Ciência e Tecnologia em Entomologia Molecular · BRUniversidade Metropolitana de Santos · BRUniversidade de São Paulo · BRUniversity of Miami · US

Funding

No grant is acknowledged in the PubMed record.

6 · The paper itself

Abstract

A variety of signaling pathways are involved in the induction of innate cytokines and CD8

Indexed as

AnimalsCD8-Positive T-LymphocytesCell LineChagas DiseaseChemokine CXCL9CytokinesImmunity, InnateInterferon-gammaInterleukin-12MacrophagesMembrane ProteinsMiceMice, Inbred BALB CMice, Inbred C57BLMice, KnockoutParasitemiaChemokine CXCL9CytokinesInterferon-gammaInterleukin-12Membrane ProteinsPerforinSting1 protein, mouseSTING ProteinCD8+ T cellIFN-βIL-12IL-6STINGTrypanosoma cruzi

Identifiers

PMID35095849
PMCPMC8795786
OpenAlexW4206842582

What OpenQuestion holds

Textmetadata
LicenceCC BY
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.