Evidence map›Paper›PMID 35095842›Full record

ArticleFrontiers in immunology2021

The Antibacterial Activity of Erythrocytes From Goose

Youcheng Yang, Jiajun Chen, Linqing Lu, Zizheng Xu, Feng Li, Minxuan Yang, Jun Li, Li Lin, Zhendong Qin

Open access · goldAbstract read
PubMed Full text at PMC Publisher
In one paragraph

Article in Frontiers in immunology, 2021. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 4 papers.

0numbers the graph read from it
0cells of the map it votes in
4citing papers in PubMed
1.1field-weighted citation impact, top 25% of its field
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

4 citing papers in PubMed, 10 citations in OpenAlex.

  1. Article
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4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

9 authors at 2 institutions in 2 countries.

Youcheng YangGuangdong Provincial Water Environment and Aquatic Products Security Engineering Technology Research Center, Guangdong Province Key Laboratory of Waterfowl Healthy Breeding, College of Animal Sciences and Technology, Zhongkai University of Agriculture and Engineering, Guangzhou, China.
Jiajun ChenGuangdong Provincial Water Environment and Aquatic Products Security Engineering Technology Research Center, Guangdong Province Key Laboratory of Waterfowl Healthy Breeding, College of Animal Sciences and Technology, Zhongkai University of Agriculture and Engineering, Guangzhou, China.
Linqing LuGuangdong Provincial Water Environment and Aquatic Products Security Engineering Technology Research Center, Guangdong Province Key Laboratory of Waterfowl Healthy Breeding, College of Animal Sciences and Technology, Zhongkai University of Agriculture and Engineering, Guangzhou, China.
Zizheng XuGuangdong Provincial Water Environment and Aquatic Products Security Engineering Technology Research Center, Guangdong Province Key Laboratory of Waterfowl Healthy Breeding, College of Animal Sciences and Technology, Zhongkai University of Agriculture and Engineering, Guangzhou, China.
Feng LiGuangdong Provincial Water Environment and Aquatic Products Security Engineering Technology Research Center, Guangdong Province Key Laboratory of Waterfowl Healthy Breeding, College of Animal Sciences and Technology, Zhongkai University of Agriculture and Engineering, Guangzhou, China.
Minxuan YangGuangdong Provincial Water Environment and Aquatic Products Security Engineering Technology Research Center, Guangdong Province Key Laboratory of Waterfowl Healthy Breeding, College of Animal Sciences and Technology, Zhongkai University of Agriculture and Engineering, Guangzhou, China.
Jun LiGuangdong Provincial Water Environment and Aquatic Products Security Engineering Technology Research Center, Guangdong Province Key Laboratory of Waterfowl Healthy Breeding, College of Animal Sciences and Technology, Zhongkai University of Agriculture and Engineering, Guangzhou, China.
Li LinGuangdong Provincial Water Environment and Aquatic Products Security Engineering Technology Research Center, Guangdong Province Key Laboratory of Waterfowl Healthy Breeding, College of Animal Sciences and Technology, Zhongkai University of Agriculture and Engineering, Guangzhou, China.
Zhendong QinGuangdong Provincial Water Environment and Aquatic Products Security Engineering Technology Research Center, Guangdong Province Key Laboratory of Waterfowl Healthy Breeding, College of Animal Sciences and Technology, Zhongkai University of Agriculture and Engineering, Guangzhou, China.
Zhongkai University of Agriculture and Engineering · CNLake Superior State University · US

Funding

No grant is acknowledged in the PubMed record.

6 · The paper itself

Abstract

In the lumen of blood vessels, there are large numbers of erythrocytes, which are approximately 95% of the total blood cells. Although the function of erythrocytes is to transport oxygen in the organism, recent studies have shown that mammalian and teleost erythrocytes are involved in the immune response against bacterial infections. However, the immune mechanisms used by avian erythrocytes are not yet clear. Here, we demonstrated that erythrocytes from goose have the ability to phagocytose as well as conduct antimicrobial activity. Firstly, we revealed the phagocytosis or adhesion activity of goose erythrocytes for latex beads 0.1-1.0 μm in diameter by fluorescence microscopy, and scanning and transmission electron microscopy. The low cytometry results also proved that goose erythrocytes had a wide range of phagocytic or adhesion activity for different bacteria. Followed, the low cytometry analysis data further explored that the goose erythrocytes contain the ability to produce reactive oxygen species (ROS) and inducible nitric oxide synthase (iNOS) in response to bacterial stimulation, and also up-regulated the expression of NOX family includes NOX1 and NOX5. Finally, we also found that goose erythrocytes showed a powerful antibacterial activity against all the three bacteria, meanwhile the stimulation of three kinds of bacteria up-regulated the expression of inflammatory factors, and increased the production of antioxidant enzymes to protect the cells from oxidative damage. Herein, our results demonstrate that goose Erythrocytes possess a certain phagocytic capacity and antioxidant system, and that the antimicrobial activity of erythrocytes can occurred through the production of unique respiratory burst against foreign pathogenic bacteria, which provides new clues to the interaction between bacteria and avian erythrocytes.

Indexed as

AnimalsAnti-Bacterial AgentsAntioxidantsBacteriaBacterial AdhesionErythrocytesGeeseImmunityInflammationOxidative StressPhagocytesPhagocytosisReactive Oxygen SpeciesRespiratory BurstAnti-Bacterial AgentsAntioxidantsReactive Oxygen SpeciesAnser domesticusantibacterial activityphagocytosisred blood cells (RBCs)respiratory burst

Identifiers

PMID35095842
PMCPMC8792903
OpenAlexW4205143075

What OpenQuestion holds

Textmetadata
LicenceCC BY
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.