Evidence map›Paper›PMID 35095830›Full record

ArticleFrontiers in immunology2021

Case Report: Unmanipulated Matched Sibling Donor Hematopoietic Cell Transplantation In

Maria Chitty-Lopez, Carla Duff, Gretchen Vaughn, Jessica Trotter, Hector Monforte, David Lindsay, Elie Haddad, Michael D Keller, Benjamin R Oshrine, Jennifer W Leiding

Open access · goldAbstract readCase Reports
In one paragraph

Article in Frontiers in immunology, 2021. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 5 papers.

0numbers the graph read from it
0cells of the map it votes in
5citing papers in PubMed
0.7field-weighted citation impact, top 35% of its field
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

5 citing papers in PubMed, 9 citations in OpenAlex.

  1. Trial
  2. Article
  3. Review
  4. Article
  5. Congenital Athymia: Unmet Needs and Practical Guidance.Therapeutics and clinical risk management · 2023
    Review
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

10 authors at 7 institutions in 2 countries.

Maria Chitty-LopezDivision of Pediatric Allergy and Immunology, University of South Florida, Tampa, FL, United States.
Carla DuffDivision of Pediatric Allergy and Immunology, University of South Florida, Tampa, FL, United States.
Gretchen VaughnCenter for Cell and Gene Therapy for Non-Malignant Conditions, Cancer and Blood Disorders Institute at Johns Hopkins All Children's Hospital, St. Petersburg, FL, United States.
Jessica TrotterDivision of Pediatric Allergy and Immunology, University of South Florida, Tampa, FL, United States.
Hector MonforteDepartment of Pathology, Johns Hopkins All Children's Hospital, St. Petersburg, FL, United States.
David LindsayDivision of Allergy and Immunology, Department of Pediatrics, University of Texas Medical Branch, Galveston, TX, United States.
Elie HaddadDivision of Immuno-Allergy and Rheumatology, The Centre Hospitalier Universitaire Sainte-Justine, Montreal, QC, Canada.
Michael D KellerDivision of Allergy and Immunology, Children's National Hospital, Washington, DC, United States.
Benjamin R OshrineCenter for Cell and Gene Therapy for Non-Malignant Conditions, Cancer and Blood Disorders Institute at Johns Hopkins All Children's Hospital, St. Petersburg, FL, United States.
Jennifer W LeidingDivision of Allergy and Immunology, Department of Pediatrics, Johns Hopkins University, Baltimore, MD, United States.
University of South Florida · USJohns Hopkins All Children's Hospital · USCentre Hospitalier Universitaire Sainte-Justine · CAChildren's National · USJohns Hopkins Medicine · USJohns Hopkins University · USThe University of Texas Medical Branch at Galveston · US

Funding

No grant is acknowledged in the PubMed record.

6 · The paper itself

Abstract

Congenital athymia can present with severe T cell lymphopenia (TCL) in the newborn period, which can be detected by decreased T cell receptor excision circles (TRECs) on newborn screening (NBS). The most common thymic stromal defect causing selective TCL is 22q11.2 deletion syndrome (22q11.2DS).

Indexed as

FemaleHematopoietic Stem Cell TransplantationHumansImmunologic Deficiency SyndromesInfant, NewbornSevere Combined ImmunodeficiencySiblingsT-Box Domain ProteinsThymus GlandT-Box Domain ProteinsTBX1 protein, humanadenoviremiadefinitive treatmenthematopoietic-stem-cell-transplantationnewborn screening (NBS)TBX1 congenital athymia

Identifiers

PMID35095830
PMCPMC8794793
OpenAlexW4205104224

What OpenQuestion holds

Textmetadata
LicenceCC BY
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.