Accelerated Development With Increased Bone Mass and Skeletal Response to Loading Suggest Receptor Activity Modifying Protein-3 as a Bone Anabolic Target.
Suruchi Pacharne, Matthew Livesey, Mahita Kadmiel, Ning Wang, Kathleen M Caron, Gareth O Richards, Tim M Skerry
Article in Frontiers in endocrinology, 2021. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 1 paper.
0numbers the graph read from it
0cells of the map it votes in
1citing papers in PubMed
0.1field-weighted citation impact, top 54% of its field
1 · What the graph read from it
What it found
Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.
The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.
2 · The registry
The trial behind it
Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.
Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.
3 · Its place in the literature
Who cites it
1 citing paper in PubMed, 1 citations in OpenAlex.
PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.
5 · Who and what money
Authors and funding
7 authors at 2 institutions in 2 countries.
Suruchi PacharneDepartment of Oncology and Metabolism, School of Medicine, University of Sheffield, Sheffield, United Kingdom.
Matthew LiveseyDepartment of Oncology and Metabolism, School of Medicine, University of Sheffield, Sheffield, United Kingdom.
Mahita KadmielDepartment of Cell Biology and Physiology, University of North Carolina at Chapel Hill, Chapel Hill, NC, United States.
Ning WangDepartment of Oncology and Metabolism, School of Medicine, University of Sheffield, Sheffield, United Kingdom.
Kathleen M CaronDepartment of Cell Biology and Physiology, University of North Carolina at Chapel Hill, Chapel Hill, NC, United States.
Gareth O RichardsDepartment of Oncology and Metabolism, School of Medicine, University of Sheffield, Sheffield, United Kingdom.
Tim M SkerryDepartment of Oncology and Metabolism, School of Medicine, University of Sheffield, Sheffield, United Kingdom.
University of Sheffield · GBUniversity of North Carolina at Chapel Hill · US
Funding
GPCR-mediated pathways for regulation of intestinal lymphatic functionR01DK119145 · NIDDK · UNIV OF NORTH CAROLINA CHAPEL HILL · PI CARON, KATHLEEN M · 2019 to 2023
$2.6M
CARDIOVASCULAR EFFECTS OF THE ADRENOMEDULLIN GENEF32HL010344 · NHLBI · UNIVERSITY OF NORTH CAROLINA CHAPEL HILL · PI CARON, KATHLEEN M · 2000 to 2001
$49k
Biotechnology and Biological Sciences Research Council BB/F008392/1Biotechnology and Biological Sciences Research Council S17443/2Biotechnology and Biological Sciences Research Council S18293/2NHLBI NIH HHS F32 HL010344NIDDK NIH HHS R01 DK119145
6 · The paper itself
Abstract
Knockout technologies provide insights into physiological roles of genes. Studies initiated into endocrinology of heteromeric G protein-coupled receptors included deletion of receptor activity modifying protein-3, an accessory protein that alters ligand selectivity of calcitonin and calcitonin-like receptors. Initially, deletion of
Indexed as
Intracellular Signaling Peptides and ProteinsMembrane ProteinsAnimalsMiceMice, KnockoutReceptor Activity-Modifying Protein 1Receptor Activity-Modifying Protein 2Receptor Activity-Modifying Protein 3Receptor Activity-Modifying ProteinsIntracellular Signaling Peptides and ProteinsMembrane ProteinsReceptor Activity-Modifying Protein 1Receptor Activity-Modifying Protein 2Receptor Activity-Modifying Protein 3Receptor Activity-Modifying Proteinsageingboneendocrinologyosteoporosisreceptor activity modifying protein
Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.
Accelerated Development With Increased Bone Mass and Skeletal Response to Loading Suggest Receptor Activity Modifying Protein-3 as a Bone Anabolic Target. · full record | OpenQuestion