Evidence map›Paper›PMID 35095756›Full record

ArticleFrontiers in endocrinology2021

The Independent Association of TSH and Free Triiodothyronine Levels With Lymphocyte Counts Among COVID-19 Patients.

David Tak Wai Lui, Chi Ho Lee, Wing Sun Chow, Alan Chun Hong Lee, Anthony Raymond Tam, Polly Pang, Tip Yin Ho, Chloe Yu Yan Cheung, Carol Ho Yi Fong, Chun Yiu Law and 6 more

Open access · goldAbstract read
In one paragraph

Article in Frontiers in endocrinology, 2021. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 12 papers, 1 of them a synthesis that pooled it.

0numbers the graph read from it
0cells of the map it votes in
12citing papers in PubMed, 1 pooled it
1.4field-weighted citation impact, top 18% of its field
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

12 citing papers in PubMed, 1 synthesis or guideline pooled it, 14 citations in OpenAlex.

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  4. Sunscreen compound benzophenone-3 and its relationship with white blood cell counts.Skin research and technology : official journal of International Society for Bioengineering and the Skin (ISBS) [and] International Society for Digital Imaging of Skin (ISDIS) [and] International Society for Skin Imaging (ISSI) · 2024
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4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

16 authors at 2 institutions in 2 countries.

David Tak Wai LuiDepartment of Medicine, The University of Hong Kong, Queen Mary Hospital Hong Kong, Hong Kong SAR, China.
Chi Ho LeeDepartment of Medicine, The University of Hong Kong, Queen Mary Hospital Hong Kong, Hong Kong SAR, China.
Wing Sun ChowDepartment of Medicine, The University of Hong Kong, Queen Mary Hospital Hong Kong, Hong Kong SAR, China.
Alan Chun Hong LeeDepartment of Medicine, The University of Hong Kong, Queen Mary Hospital Hong Kong, Hong Kong SAR, China.
Anthony Raymond TamDepartment of Medicine, The University of Hong Kong, Queen Mary Hospital Hong Kong, Hong Kong SAR, China.
Polly PangDepartment of Medicine, The University of Hong Kong, Queen Mary Hospital Hong Kong, Hong Kong SAR, China.
Tip Yin HoDepartment of Medicine, The University of Hong Kong, Queen Mary Hospital Hong Kong, Hong Kong SAR, China.
Chloe Yu Yan CheungDepartment of Medicine, The University of Hong Kong, Queen Mary Hospital Hong Kong, Hong Kong SAR, China.
Carol Ho Yi FongDepartment of Medicine, The University of Hong Kong, Queen Mary Hospital Hong Kong, Hong Kong SAR, China.
Chun Yiu LawDivision of Chemical Pathology, Queen Mary Hospital Hong Kong, Hong Kong SAR, China.
Kelvin Kai Wang ToDepartment of Microbiology, The University of Hong Kong, Queen Mary Hospital Hong Kong, Hong Kong SAR, China.
Ching Wan LamDepartment of Pathology, The University of Hong Kong Hong Kong, Hong Kong SAR, China.
Kathryn Choon Beng TanDepartment of Medicine, The University of Hong Kong, Queen Mary Hospital Hong Kong, Hong Kong SAR, China.
Yu Cho WooDepartment of Medicine, The University of Hong Kong, Queen Mary Hospital Hong Kong, Hong Kong SAR, China.
Ivan Fan Ngai HungDepartment of Medicine, The University of Hong Kong, Queen Mary Hospital Hong Kong, Hong Kong SAR, China.
Karen Siu Ling LamDepartment of Medicine, The University of Hong Kong, Queen Mary Hospital Hong Kong, Hong Kong SAR, China.
University of Hong Kong · HKQueen Mary Hospital · CN

Funding

No grant is acknowledged in the PubMed record.

6 · The paper itself

Abstract

Background: Both lymphopenia and thyroid dysfunction are commonly observed among COVID-19 patients. Whether thyroid function independently correlates with lymphocyte counts (LYM) remains to be elucidated. Methods: We included consecutive adults without known thyroid disorder admitted to Queen Mary Hospital for COVID-19 from July 2020 to April 2021 who had thyroid-stimulating hormone (TSH), free thyroxine (fT4), free triiodothyronine (fT3) and LYM measured on admission. Results: A total of 541 patients were included. Median LYM was 1.22 x 10 Conclusion: TSH and fT3 levels showed independent positive correlations with LYM among COVID-19 patients, supporting the interaction between the hypothalamic-pituitary-thyroid axis and immune system in COVID-19.

Indexed as

AdultAgedChinaCOVID-19FemaleHospitalizationHumansLymphocyte CountLymphocytesLymphopeniaMaleMiddle AgedSARS-CoV-2Thyroid DiseasesThyroid Function TestsThyroid HormonesThyroid HormonesThyrotropinTriiodothyronineCOVID-19euthyroid sick syndromeslymphocyteslymphopeniaSARS-CoV-2thyroid function tests

Identifiers

PMID35095756
PMCPMC8792436
OpenAlexW4205832290

What OpenQuestion holds

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LicenceCC BY
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Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.