ArticleFrontiers in neurology2021
The Benefit of Thrombectomy in Patients With Low ASPECTS Is a Matter of Shades of Gray-What Current Trials May Have Missed.
Article in Frontiers in neurology, 2021. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 17 papers.
What it found
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The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.
The trial behind it
Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.
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Who cites it
17 citing papers in PubMed, 23 citations in OpenAlex.
- Association of 24-Hour Computed Tomography Infarct Density on Functional Outcomes in Stroke: Secondary Analysis From the AcT Trial.Journal of the American Heart Association · 2026Trial
- Oedema reduction mediates thrombectomy benefit in large core stroke: secondary analysis of the TENSION trial.European stroke journal · 2026Trial
- Review
- Clinical Implications of Stroke Progressor Phenotypes defined based on ASPECTS decay and perfusion estimated infarct growth rate: insights from a large national thrombectomy registry.Neurological sciences : official journal of the Italian Neurological Society and of the Italian Society of Clinical Neurophysiology · 2026Article
- Large Core Trial.AJNR. American journal of neuroradiology · 2025Review
- Challenges in Translating Recent RCTs on Endovascular Therapy for Large Core Infarctions Into Real-World Practice.Journal of clinical neurology (Seoul, Korea) · 2025Article
- Current perspective in acute ischemic stroke: net water uptake and imaging-guided selection as bridges to personalized, tissue-based care.Frontiers in neurology · 2025Article
- Thrombectomy for Stroke With Large Infarct on Noncontrast CT: The TESLA Randomized Clinical Trial.JAMA · 2024Article
- Haemorrhage after thrombectomy with adjuvant thrombolysis in unknown onset stroke depends on high early lesion water uptake.Stroke and vascular neurology · 2024Article
- MRI of cerebral oedema in ischaemic stroke and its current use in routine clinical practice.Neuroradiology · 2024Review
- Novel advanced imaging techniques for cerebral oedema.Frontiers in neurology · 2024Review
- Revolutionizing the Management of Large-Core Ischaemic Strokes: Decoding the Success of Endovascular Therapy in the Recent Stroke Trials.Journal of cardiovascular development and disease · 2023Review
- Stroke Thrombectomy in the Elderly: Efficacy, Safety, and Special Considerations.Stroke (Hoboken, N.J.) · 2023Review
- Article
- Venous Outflow Profiles Are Linked to Clinical Outcomes in Ischemic Stroke Patients with Extensive Baseline Infarct.Journal of stroke · 2022Article
- Decision-making strategies for reperfusion therapies: navigating through stroke trials gaps.Arquivos de neuro-psiquiatria · 2022Article
- Net water uptake and ASPECTS in predicting futile recanalization for acute large vessel occlusion stroke: insights from time window stratification.Frontiers in neurologyArticle
Corrections and comments
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Authors and funding
7 authors at 3 institutions in 1 country.
Funding
No grant is acknowledged in the PubMed record.
Abstract
Randomized trials supporting the benefit of endovascular treatment in acute ischemic stroke patients with a large early infarction are not yet available. Few retrospective studies exist that suggest a potential positive treatment effect on functional outcome, as well as procedural safety. However, potential benefit or harm of MT in patients with low initial ASPECTS is still a subject of current debate, and in particular, how to select these patients for treatment. The purpose of this pilot study was to evaluate how early tissue water uptake in acute ischemic brain might determine lesion fate and functional outcome in low ASPECTS patients undergoing MT. We observed that the degree of early water uptake measured by quantitative NWU was significantly associated with functional outcome in low ASPECTS patients, yielding a higher diagnostic power compared to other parameters such as ASPECTS, age, or NIHSS. No conclusive evidence of a beneficial effect of successful reperfusion was observed in patients with low ASPECTS and high NWU, which highlights the potential of NWU as a tool to specify patient selection.
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Registered trials
Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.