Evidence map›Paper›PMID 35095551›Full record

ReviewFrontiers in physiology2021

Influence of High Hemoglobin-Oxygen Affinity on Humans During Hypoxia.

Kevin L Webb, Paolo B Dominelli, Sarah E Baker, Stephen A Klassen, Michael J Joyner, Jonathon W Senefeld, Chad C Wiggins

Open access · goldAbstract readReview
In one paragraph

Review in Frontiers in physiology, 2021. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 20 papers.

0numbers the graph read from it
0cells of the map it votes in
20citing papers in PubMed
8.4field-weighted citation impact, top 2% of its field
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

20 citing papers in PubMed, 47 citations in OpenAlex.

  1. Trial
  2. Article
  3. Role of channels in the ObioRxiv : the preprint server for biology · 2025
    Article
  4. Article
  5. Article
  6. Article
  7. Article
  8. Article
  9. Article
  10. Exercise performance reduction and preventive measures in highland sports.Zhong nan da xue xue bao. Yi xue ban = Journal of Central South University. Medical sciences · 2023
    Article
  11. Polymerized human hemoglobin with low and high oxygen affinity in trauma models.Translational research : the journal of laboratory and clinical medicine · 2023
    Article
  12. Review
  13. Exercise and Experiments of Nature.Comprehensive Physiology · 2023
    Article
  14. Attenuated cardiac autonomic function in humans with high-affinity hemoglobin and compensatory polycythemia.American journal of physiology. Regulatory, integrative and comparative physiology · 2023
    Article
  15. Review
  16. Review
  17. Article
  18. Drug transport by red blood cells.Frontiers in physiology · 2023
    Review
  19. Review
  20. Article
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

7 authors at 3 institutions in 2 countries.

Kevin L WebbDepartment of Anesthesiology and Perioperative Medicine, Mayo Clinic, Rochester, MN, United States.
Paolo B DominelliDepartment of Kinesiology, University of Waterloo, Waterloo, ON, Canada.
Sarah E BakerDepartment of Anesthesiology and Perioperative Medicine, Mayo Clinic, Rochester, MN, United States.
Stephen A KlassenDepartment of Anesthesiology and Perioperative Medicine, Mayo Clinic, Rochester, MN, United States.
Michael J JoynerDepartment of Anesthesiology and Perioperative Medicine, Mayo Clinic, Rochester, MN, United States.
Jonathon W SenefeldDepartment of Anesthesiology and Perioperative Medicine, Mayo Clinic, Rochester, MN, United States.
Chad C WigginsDepartment of Anesthesiology and Perioperative Medicine, Mayo Clinic, Rochester, MN, United States.
Mayo Clinic in Arizona · USBrock University · CAUniversity of Waterloo · CA

Funding

Variant Hemoglobin and Cardiorespiratory Regulation in HumansR35HL139854 · NHLBI · MAYO CLINIC ROCHESTER · PI JOYNER, MICHAEL J · 2018 to 2024
$5.8M
NHLBI NIH HHS R35 HL139854
6 · The paper itself

Abstract

Humans elicit a robust series of physiological responses to maintain adequate oxygen delivery during hypoxia, including a transient reduction in hemoglobin-oxygen (Hb-O

Indexed as

altitude acclimatizationexercisehigh affinity hemoglobin (Hb)high-altitudeoxygen transportVO2max (maximal oxygen uptake)

Identifiers

PMID35095551
PMCPMC8795792
OpenAlexW4206411001

What OpenQuestion holds

Textmetadata
LicenceCC BY
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.