ReviewFrontiers in physiology2021
Computational Modeling Intervertebral Disc Pathophysiology: A Review.
Review in Frontiers in physiology, 2021. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 27 papers.
What it found
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The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.
The trial behind it
Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.
Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.
Who cites it
27 citing papers in PubMed, 35 citations in OpenAlex.
- Surviving the Nucleus Pulposus Desert: Next-Generation Strategies for Intervertebral Disc Cell Therapy.JOR spine · 2026Article
- Defining the Human Nucleus Pulposus Microenvironment and Its Impact on Cell Matrix Synthesis and Metabolic Activity.JOR spine · 2026Article
- The Biomechanical Landscape of Lumbar Disc Herniation: Mechanobiological Insights Into Injury and Regeneration.Neurospine · 2026Review
- Finite element models of intervertebral disc: recent advances and prospects.Annals of medicine · 2025Review
- Optimisation of Intervertebral Disc Mechanical Properties and the Impact of Vertebral Alignment in Subject-Specific Finite Element Models.International journal for numerical methods in biomedical engineering · 2025Article
- Development of a spinopelvic complex finite element model for quantitative analysis of the biomechanical response of patients with degenerative spondylolisthesis.Medical & biological engineering & computing · 2025Article
- Biomechanical evaluation of oblique lateral interbody fusion with various fixation methods for degenerative lumbar scoliosis: a finite element analysis considering different bone densities.Frontiers in bioengineering and biotechnology · 2025Article
- A comparative study of the effect of facet tropism on the index-level kinematics and biomechanics after artificial cervical disc replacement (ACDR) with Prestige LP, Prodisc-C vivo, and Mobi-C: a finite element study.Journal of orthopaedic surgery and research · 2024Article
- The effect of large channel-based foraminoplasty on lumbar biomechanics in percutaneous endoscopic discectomy: a finite element analysis.Journal of orthopaedic surgery and research · 2024Article
- Understanding the etiopathogenesis of lumbar intervertebral disc herniation: From clinical evidence to basic scientific research.JOR spine · 2024Review
- Finite element analysis of different pedicle screw internal fixations for first lumbar vertebral fracture in different sports conditions.The Journal of international medical research · 2024Article
- Effect of cement volume on biomechanical response of a spine segment treated with a PEEK polymer implant: a finite element comparative study with vertebroplasty.Frontiers in bioengineering and biotechnology · 2024Article
- Biomechanical assessment of anterior plate system, bilateral pedicle screw and transdiscal screw system for high-grade spondylolisthesis: a finite element study.Frontiers in bioengineering and biotechnology · 2024Article
- Biomechanical analysis of the tandem spinal external fixation in a multiple-level noncontiguous lumbar fractures model: a finite element analysis.Frontiers in bioengineering and biotechnology · 2024Article
- Analyzing isolated degeneration of lumbar facet joints: implications for degenerative instability and lumbar biomechanics using finite element analysis.Frontiers in bioengineering and biotechnology · 2024Article
- The impact of disc degeneration on the dynamic characteristics of the lumbar spine: a finite element analysis.Frontiers in bioengineering and biotechnology · 2024Article
- Does the novel artificial cervical joint complex resolve the conflict between stability and mobility after anterior cervical surgery? a finite element study.Frontiers in bioengineering and biotechnology · 2024Article
- Effectivity of puncture method for intervertebral disc degeneration animal models: review article.Annals of medicine and surgery (2012) · 2023Article
- Cytokine Imbalance as a Biomarker of Intervertebral Disk Degeneration.International journal of molecular sciences · 2023Review
- Endplate role in the degenerative disc disease: A brief review.World journal of clinical cases · 2023Review
Corrections and comments
PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.
Authors and funding
4 authors at 2 institutions in 1 country.
Funding
No grant is acknowledged in the PubMed record.
Abstract
Lower back pain is a medical condition of epidemic proportion, and the degeneration of the intervertebral disc has been identified as a major contributor. The etiology of intervertebral disc (IVD) degeneration is multifactorial, depending on age, cell-mediated molecular degradation processes and genetics, which is accelerated by traumatic or gradual mechanical factors. The complexity of such intertwined biochemical and mechanical processes leading to degeneration makes it difficult to quantitatively identify cause-effect relationships through experiments. Computational modeling of the IVD is a powerful investigative tool since it offers the opportunity to vary, observe and isolate the effects of a wide range of phenomena involved in the degenerative process of discs. This review aims at discussing the main findings of finite element models of IVD pathophysiology with a special focus on the different factors contributing to physical changes typical of degenerative phenomena. Models presented are subdivided into those addressing role of nutritional supply, progressive biochemical alterations stemming from an imbalance between anabolic and catabolic processes, aging and those considering mechanical factors as the primary source that induces morphological change within the disc. Limitations of the current models, as well as opportunities for future computational modeling work are also discussed.
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Registered trials
Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.