ArticleFrontiers in aging neuroscience2021
Low-Frequency vs. Theta Burst Transcranial Magnetic Stimulation for the Treatment of Chronic Non-fluent Aphasia in Stroke: A Proof-of-Concept Study.
Article in Frontiers in aging neuroscience, 2021. The graph could read no effect estimate from its abstract, so it casts no vote on the map. It is linked to 2 registered trials, which are not on this map. Cited by 16 papers, 6 of them syntheses that pooled it.
What it found
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The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.
The trial behind it
Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.
Synchronous rTMS and Computer-integrated Speech Training Applied in Aphasic Patients
Precision Neuromodulation in Post-Stroke Aphasia Using TMS
Who cites it
16 citing papers in PubMed, 6 syntheses or guidelines pooled it, 24 citations in OpenAlex.
- Neuropsychological and Anatomical-Functional Effects of Transcranial Magnetic Stimulation in Post-Stroke Patients with Cognitive Impairment and Aphasia: A Systematic Review.Neuropsychology review · 2025Pooled it
- Efficacy of Cerebellar Transcranial Magnetic Stimulation for Post-stroke Balance and Limb Motor Function Impairments: Meta-analyses of Random Controlled Trials and Resting-State fMRI Studies.Cerebellum (London, England) · 2024Pooled it
- Theta-burst stimulation as a therapeutic tool in neurological pathology: a systematic review.Neurological sciences : official journal of the Italian Neurological Society and of the Italian Society of Clinical Neurophysiology · 2024Pooled it
- Theta burst stimulation: what role does it play in stroke rehabilitation? A systematic review of the existing evidence.BMC neurology · 2024Pooled it
- Repetitive transcranial magnetic stimulation for post-stroke non-fluent aphasia: a systematic review and meta-analysis of randomized controlled trials.Frontiers in neurology · 2024Pooled it
- Comparative Efficacy of Different Repetitive Transcranial Magnetic Stimulation Protocols for Stroke: A Network Meta-Analysis.Frontiers in neurology · 2022Pooled it
- Article
- Structural-functional connectivity coupling in motor-brain networks following acute ischemic stroke.Journal of neuroengineering and rehabilitation · 2026Article
- Improving Lexicosemantic Impairments in Post-Stroke Aphasia Using rTMS Targeting the Right Anterior Temporal Lobe.Brain sciences · 2026Article
- Transcranial Magnetic Stimulation Combined with Speech-Language Therapy for Post-Stroke Aphasia Recovery: A Systematic Review and Network Meta-Analysis.Therapeutics and clinical risk management · 2026Review
- The effect of theta burst stimulation (TBS) on aphasia in stroke patients: a protocol of systematic review and meta-analysis.Systematic reviews · 2025Article
- Advances in theta-burst transcranial magnetic stimulation for auditory comprehension deficits in post-stroke aphasia.Frontiers in neurology · 2025Review
- Efficacy of different types of transcranial magnetic stimulation on post-stroke aphasia patients: a network meta-analysis.Frontiers in neurology · 2025Review
- Effects of low-frequency rTMS combined with speech and language therapy on Broca's aphasia in subacute stroke patients.Frontiers in neurology · 2024Article
- Perspective on the clinical management of post-stroke aphasia and dysphagia using repetitive transcranial magnetic stimulation (rTMS).Frontiers in neurology · 2024Article
- Prolonged intermittent theta burst stimulation for post-stroke aphasia: protocol of a randomized, double-blinded, sham-controlled trial.Frontiers in neurology · 2024Article
Corrections and comments
PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.
Authors and funding
4 authors at 2 institutions in 1 country.
Funding
No grant is acknowledged in the PubMed record.
Abstract
backgroundAlthough low-frequency repetitive transcranial magnetic stimulation (LF-rTMS) has shown promise in the treatment of poststroke aphasia, the efficacy of high-frequency rTMS (HF-rTMS) has yet to be determined. PURPOSE: We investigated the efficacy of intermittent theta burst stimulation (iTBS) in ameliorating chronic non-fluent aphasia and compared it with that of LF-rTMS.
methodsWe randomly assigned patients with poststroke non-fluent aphasia to an ipsilesional iTBS (
resultsCompared with the sham group, the iTBS group exhibited significant improvements in conversation, description, and expression scores (
conclusionOur study findings contribute to a growing body of evidence that ipsilesional iTBS enhances the language recovery of patients with non-fluent aphasia after a chronic stroke. Auditory comprehension was more preferentially enhanced by iTBS compared with the 1-Hz protocol. Our findings highlight the importance of ipsilesional modulation through excitatory rTMS for the recovery of non-fluent aphasia in patients with chronic stroke. CLINICAL
trial registration[www.ClinicalTrials.gov], identifier [NCT03059225].
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Registered trials
Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.