ArticleFrontiers in aging neuroscience2021
Monthly At-Home Computerized Cognitive Testing to Detect Diminished Practice Effects in Preclinical Alzheimer's Disease.
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In one paragraph
Article in Frontiers in aging neuroscience, 2021. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 44 papers, 1 of them a synthesis that pooled it.
0numbers the graph read from it
0cells of the map it votes in
44citing papers in PubMed, 1 pooled it
7.5field-weighted citation impact, top 2% of its field
What it found
Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.
The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.
The trial behind it
Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.
Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.
Who cites it
44 citing papers in PubMed, 1 synthesis or guideline pooled it, 51 citations in OpenAlex.
- Validation status of cognitive digital assessments by the FDA BEST framework and context of use in preclinical AD studies: A systematic review.Alzheimer's & dementia : the journal of the Alzheimer's Association · 2025Pooled it
- Digital memory assessments and plasma pTau217 enable efficient preclinical Alzheimer's trials.The journal of prevention of Alzheimer's disease · 2026Trial
- Pepinemab antibody blockade of SEMA4D in early Huntington's disease: a randomized, placebo-controlled, phase 2 trial.Nature medicine · 2022Trial
- Digital cognitive phenotyping enhances risk stratification in preclinical Alzheimer's disease.Alzheimer's & dementia : the journal of the Alzheimer's Association · 2026Article
- Modernizing cognitive assessment in Alzheimer's disease.Nature aging · 2026Article
- A real-world feasibility study: at home longitudinal use of the Cumulus NeuLogiq® platform for electrophysiological and neurocognitive measures in patients with mild Alzheimer's Disease dementia.Frontiers in digital health · 2026Article
- Lower locus coeruleus integrity is associated with diminished practice effects in clinically unimpaired older individuals.Neurobiology of aging · 2025Article
- Sex differences in cognitive trajectories and practice effects in a cohort of older Londoners: The role of risk factors.Journal of Alzheimer's disease : JAD · 2025Article
- Integrating plasma p-tau217 and digital cognitive assessments for early detection in Alzheimer's disease.Alzheimer's & dementia : the journal of the Alzheimer's Association · 2025Article
- Smartphone- and Tablet-Based Tools to Assess Cognition in Individuals With Preclinical Alzheimer Disease and Mild Cognitive Impairment: Scoping Review.Journal of medical Internet research · 2025Article
- A scoping review of remote and unsupervised digital cognitive assessments in preclinical Alzheimer's disease.NPJ digital medicine · 2025Article
- Amyloid-Beta Deposition in Basal Frontotemporal Cortex Is Associated with Selective Disruption of Temporal Mnemonic Discrimination.The Journal of neuroscience : the official journal of the Society for Neuroscience · 2025Article
- Decreased practice effects in cognitively unimpaired amyloid betapositive individuals: a multicenter, longitudinal, cohort study.Alzheimer's & dementia : the journal of the Alzheimer's Association · 2025Article
- Acceptance of Unsupervised App-Based Cognitive Assessment in Outpatient Care: An Implementation Study.JMIR formative research · 2025Article
- Detecting early cognitive deficits in preclinical Alzheimer's disease using a remote digital multi-day learning paradigm.NPJ digital medicine · 2025Article
- How's Your Memory? Convergence of Objective and Subjective Memory Performance Using Ambulatory Assessment in Middle Age.Innovation in aging · 2025Article
- Characterizing Performance on a Suite of English-Language NeuroUX Mobile Cognitive Tests in a US Adult Sample: Ecological Momentary Cognitive Testing Study.Journal of medical Internet research · 2024Article
- Digital cognitive assessments as low-burden markers for predicting future cognitive decline and tau accumulation across the Alzheimer's spectrum.Alzheimer's & dementia : the journal of the Alzheimer's Association · 2024Article
- Cognitive modeling of the Mnemonic Similarity Task as a digital biomarker for Alzheimer's disease.Alzheimer's & dementia : the journal of the Alzheimer's Association · 2024Article
- Amyloid-β deposition in basal frontotemporal cortex is associated with selective disruption of temporal mnemonic discrimination.bioRxiv : the preprint server for biology · 2024Article
Corrections and comments
PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.
Authors and funding
13 authors at 6 institutions in 2 countries.
Roos J JuttenDepartment of Neurology, Massachusetts General Hospital and Harvard Medical School, Boston, MA, United States.
Dorene M RentzDepartment of Neurology, Massachusetts General Hospital and Harvard Medical School, Boston, MA, United States.
Jessie F FuDepartment of Radiology, Massachusetts General Hospital and Harvard Medical School, Boston, MA, United States.
Danielle V MayblyumDepartment of Radiology, Massachusetts General Hospital and Harvard Medical School, Boston, MA, United States.
Rebecca E AmariglioDepartment of Neurology, Massachusetts General Hospital and Harvard Medical School, Boston, MA, United States.
Rachel F BuckleyDepartment of Neurology, Massachusetts General Hospital and Harvard Medical School, Boston, MA, United States.
Michael J ProperziDepartment of Neurology, Massachusetts General Hospital and Harvard Medical School, Boston, MA, United States.
Paul MaruffCogState Ltd., Melbourne, VIC, Australia.
Craig E StarkDepartment of Neurobiology and Behavior, Center for the Neurobiology of Learning and Memory, University of California, Irvine, Irvine, CA, United States.
Michael A YassaDepartment of Neurobiology and Behavior, Center for the Neurobiology of Learning and Memory, University of California, Irvine, Irvine, CA, United States.
Keith A JohnsonDepartment of Neurology, Massachusetts General Hospital and Harvard Medical School, Boston, MA, United States.
Reisa A SperlingDepartment of Neurology, Massachusetts General Hospital and Harvard Medical School, Boston, MA, United States.
Kathryn V PappDepartment of Neurology, Massachusetts General Hospital and Harvard Medical School, Boston, MA, United States.
Massachusetts General Hospital · USHarvard University · USBrigham and Women's Hospital · USUniversity of California, Irvine · USFlorey Institute of Neuroscience and Mental Health · AUUniversity of Melbourne · AU
Funding
Vascular factors, physical activity, and inflammation as modulators of neurodegenerative and cognitive trajectories (Project 2)P01AG036694 · NIA · MASSACHUSETTS GENERAL HOSPITAL · PI Rachel Frances Buckley · 2010 to 2026
$50.2MResearch Education ComponentP30AG062421 · NIA · MASSACHUSETTS GENERAL HOSPITAL · PI STEVEN E ARNOLD · 2019 to 2026
$36.5MThe Alzheimer's Disease Research Center at the University of California, IrvineP30AG066519 · NIA · UNIVERSITY OF CALIFORNIA-IRVINE · PI Elizabeth Head · 2020 to 2026
$27.9MDevelopment of the mnemonic similarity task as a tool to address age and dementia-related memory declineR01AG066683 · NIA · UNIVERSITY OF CALIFORNIA-IRVINE · PI STARK, CRAIG E · 2020 to 2024
$1.9MDevelopment and validation of efficient cognitive composite scores of digital tools for the detection of early pathophysiological changes in Alzheimers diseaseK99AG081457 · NIA · MASSACHUSETTS GENERAL HOSPITAL · PI FU, FANG LU (JESSIE) · 2023 to 2024
$254kNIA NIH HHS K99 AG081457NIA NIH HHS P01 AG036694NIA NIH HHS P30 AG062421NIA NIH HHS P30 AG066519NIA NIH HHS R01 AG066683
Abstract
PubMed holds no abstract for this paper.
Indexed as
computerized testingdigital biomarkerspractice effectspreclinical ADremote assessment
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LicenceCC BY
Read underepoch 390
Registered trials
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Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.