Evidence map›Paper›PMID 35094960›Full record

ReviewTrends in cancer2022

Diversity upon diversity: linking DNA double-strand break repair to blood cancer health disparities.

Jason N Sterrenberg, Melissa L Folkerts, Valeria Rangel, Sarah Eugenie Lee, Nicholas R Pannunzio

Open access · greenAbstract readReview
PubMed Full text at PMC Publisher
In one paragraph

Review in Trends in cancer, 2022. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 6 papers.

0numbers the graph read from it
0cells of the map it votes in
6citing papers in PubMed
0.6field-weighted citation impact, top 37% of its field
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

6 citing papers in PubMed, 7 citations in OpenAlex.

  1. Article
  2. Review
  3. Article
  4. Article
  5. Review
  6. Review
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

5 authors at 1 institution in 1 country.

Jason N SterrenbergDepartment of Medicine, Division of Hematology/Oncology, University of California at Irvine, Irvine, CA 92697, USA.
Melissa L FolkertsDepartment of Biological Chemistry, University of California at Irvine, Irvine, CA 92697, USA.
Valeria RangelDepartment of Biological Chemistry, University of California at Irvine, Irvine, CA 92697, USA.
Sarah Eugenie LeeSchool of Biological Sciences, University of California at Irvine, Irvine, CA 92697, USA.
Nicholas R PannunzioDepartment of Medicine, Division of Hematology/Oncology, University of California at Irvine, Irvine, CA 92697, USA; Department of Biological Chemistry, University of California at Irvine, Irvine, CA 92697, USA; Chao Family Comprehensive Cancer Center, University of California at Irvine, Irvine, CA 92697, USA. Electronic address: nrpann@hs.uci.edu.
University of California, Irvine · US

Funding

Rapid detection of CRLF2 rearrangements in Hispanic Ph-like ALL patients to access diagnosis and relapseR37CA266042 · NCI · UNIVERSITY OF CALIFORNIA-IRVINE · PI Nicholas Pannunzio · 2022 to 2026
$2.5M
NCI NIH HHS R37 CA266042
6 · The paper itself

Abstract

Chromosomal translocations arising from aberrant repair of multiple DNA double-strand breaks (DSBs) are a defining characteristic of many cancers. DSBs are an essential part of physiological processes in antibody-producing B cells. The B cell environment is poised to generate genome instability leading to translocations relevant to the pathology of blood cancers. These are a diverse set of cancers, but limited data from under-represented groups have pointed to health disparities associated with each. We focus on the DSBs that occur in developing B cells and propose the most likely mechanism behind the formation of translocations. We also highlight specific cancers in which these rearrangements occur and address the growing concern of health disparities associated with them.

Indexed as

DNA Breaks, Double-StrandedNeoplasmsDNADNA End-Joining RepairDNA RepairHumansDNAB cellscancer health disparitieschromosomal translocationsDNA repairnon-homologous end joiningV(D)J recombination

Identifiers

PMID35094960
PMCPMC9248772
OpenAlexW4210481778

What OpenQuestion holds

Textmetadata
LicenceTDM
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.