Evidence map›Paper›PMID 35094945›Full record

ReviewTrends in immunology2022

Fate-mapping mice: new tools and technology for immune discovery.

Scarlett E Lee, Brian D Rudd, Norah L Smith

Abstract readReview
In one paragraph

Review in Trends in immunology, 2022. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 8 papers.

0numbers the graph read from it
0cells of the map it votes in
8citing papers in PubMed
–field-weighted citation impact
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

8 citing papers in PubMed.

  1. Article
  2. Article
  3. Review
  4. Article
  5. Article
  6. Review
  7. Macrophage Fate Mapping.Current protocols · 2022
    Article
  8. Review
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

3 authors.

Scarlett E LeeDepartment of Microbiology and Immunology, Cornell University, Ithaca, NY 14850, USA.
Brian D RuddDepartment of Microbiology and Immunology, Cornell University, Ithaca, NY 14850, USA.
Norah L SmithDepartment of Microbiology and Immunology, Cornell University, Ithaca, NY 14850, USA. Electronic address: nls12@cornell.edu.

Funding

Graduate Training Program in Comparative MedicineT32OD011000 · OD · CORNELL UNIVERSITY · PI Amanda Marjorie DE MESTRE · 2012 to 2026
$5.7M
The developmental layers in the CD8+ T cell response to chronic infectionR01AI110613 · NIAID · CORNELL UNIVERSITY · PI GRIMSON, ANDREW W, RUDD, BRIAN DAVID · 2014 to 2022
$4.1M
Mechanisms Limiting Neonatal ImmunityR01AI105265 · NIAID · CORNELL UNIVERSITY · PI RUDD, BRIAN DAVID · 2014 to 2023
$4.0M
Roles for DevelopmentallyRegulated microRNAs in Neonatal ImmunityU01AI131348 · NIAID · CORNELL UNIVERSITY · PI GRIMSON, ANDREW W, RUDD, BRIAN DAVID · 2017 to 2021
$2.2M
Impact of early microbial exposure on immune ontogenyR01HD107798 · NICHD · CORNELL UNIVERSITY · PI DAVENPORT, MILES PHILIP, RUDD, BRIAN DAVID · 2021 to 2023
$1.4M
Developmental layers in the CD8+ T cell response to infection.R21AI138025 · NIAID · CORNELL UNIVERSITY · PI SMITH, NORAH L · 2019 to 2020
$430k
DWNT-2 FUNCTION IN DROSOPHILAF32HD007798 · NICHD · STANFORD UNIVERSITY · PI KOZOPAS, KAREN M · 1995 to 1996
–
NIAID NIH HHS R01 AI105265NIAID NIH HHS R01 AI110613NIAID NIH HHS R21 AI138025NIAID NIH HHS U01 AI131348NICHD NIH HHS F32 HD007798NICHD NIH HHS R01 HD107798NIH HHS T32 OD011000
6 · The paper itself

Abstract

The fate-mapping mouse has become an essential tool in the immunologist's toolbox. Although traditionally used by developmental biologists to trace the origins of cells, immunologists are turning to fate-mapping to better understand the development and function of immune cells. Thus, an expansion in the variety of fate-mapping mouse models has occurred to answer fundamental questions about the immune system. These models are also being combined with new genetic tools to study cancer, infection, and autoimmunity. In this review, we summarize different types of fate-mapping mice and describe emerging technologies that might allow immunologists to leverage this valuable tool and expand our functional knowledge of the immune system.

Indexed as

TechnologyAnimalsCell LineageHumansMiceMice, TransgenicCre-loxPfate mappingimmune developmentlineage tracingmouse models

Identifiers

PMID35094945
PMCPMC8882138

What OpenQuestion holds

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Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.