Evidence map›Paper›PMID 35094878›Full record

ArticleHuman immunology2022

Identification of a CD4

Thai H Ho, Kirsten Pfeffer, Glen J Weiss, Yvette Ruiz, Douglas F Lake

Open access · greenAbstract read
PubMed Full text at PMC Publisher
In one paragraph

Article in Human immunology, 2022. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 4 papers.

0numbers the graph read from it
0cells of the map it votes in
4citing papers in PubMed
0.4field-weighted citation impact, top 44% of its field
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

4 citing papers in PubMed, 6 citations in OpenAlex.

  1. Notch2 Directs aTreg Cell Fate Toward Immunoregulation or Inflammatory Pyroptosis.Advanced science (Weinheim, Baden-Wurttemberg, Germany) · 2026
    Article
  2. Pathogenic Role of Cytokines in Rheumatoid Arthritis.Journal of clinical medicine · 2025
    Review
  3. Review
  4. Article
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

5 authors at 3 institutions in 1 country.

Thai H HoDivision of Hematology/Oncology, Mayo Clinic Arizona, Phoenix, AZ, United States.
Kirsten PfefferSchool of Life Sciences, Arizona State University, Scottsdale, AZ, United States.
Glen J WeissUniversity of Arizona College of Medicine-Phoenix, Phoenix, AZ, United States.
Yvette RuizSchool of Life Sciences, Arizona State University, Scottsdale, AZ, United States.
Douglas F LakeSchool of Life Sciences, Arizona State University, Scottsdale, AZ, United States. Electronic address: Douglas.Lake@asu.edu.
Arizona State University · USUniversity of Arizona · USWinnMed · US

Funding

Deciphering the interplay between H3K36 and DNA methylation in renal cancerR01CA224917 · NCI · MAYO CLINIC ROCHESTER · PI HO, THAI HUU, ROBERTSON, KEITH D · 2018 to 2022
$2.9M
NCI NIH HHS R01 CA224917
6 · The paper itself

Abstract

Regulatory T cells (Tregs) suppress adaptive immunity and inflammation. Although they play a role in suppressing anti-tumor responses, development of therapeutics that target Tregs is limited by their low abundance, heterogeneity, and lack of specific cell surface markers. We isolated human PBMC-derived CD4

Indexed as

B7-H1 AntigenT-Lymphocytes, RegulatoryCD4 AntigensCell LineCell ProliferationForkhead Transcription FactorsHumansInterleukin-2 Receptor alpha SubunitLeukocytes, MononuclearB7-H1 AntigenCD4 AntigensForkhead Transcription FactorsInterleukin-2 Receptor alpha SubunitCFSE T cell suppression assaysContact-dependent suppressionRegulatory T cells

Identifiers

PMID35094878
PMCPMC8995384
OpenAlexW4210461875

What OpenQuestion holds

Textmetadata
LicenceTDM
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.