Evidence map›Paper›PMID 35094691›Full record

ArticleDiagnostic pathology2022

Identification of LMO2 as a new marker for acinic cell carcinoma of salivary gland.

Dong Sheng, Yan Zhang, Tian Xue, Xiao-Yan Zhou, Xiao-Qiu Li

Open access · goldAbstract read
PubMed Full text at PMC Publisher
In one paragraph

Article in Diagnostic pathology, 2022. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 1 paper.

0numbers the graph read from it
0cells of the map it votes in
1citing papers in PubMed
0.4field-weighted citation impact, top 40% of its field
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

1 citing paper in PubMed, 2 citations in OpenAlex.

  1. Review
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

5 authors at 2 institutions in 1 country.

Dong Sheng *Department of Pathology, Fudan University Shanghai Cancer Center, 270 Dong-An Road, Shanghai, 200032, China.
Yan Zhang *Department of Pathology, Fudan University Shanghai Cancer Center, 270 Dong-An Road, Shanghai, 200032, China.
Tian XueDepartment of Pathology, Fudan University Shanghai Cancer Center, 270 Dong-An Road, Shanghai, 200032, China.
Xiao-Yan ZhouDepartment of Pathology, Fudan University Shanghai Cancer Center, 270 Dong-An Road, Shanghai, 200032, China.
Xiao-Qiu LiDepartment of Pathology, Fudan University Shanghai Cancer Center, 270 Dong-An Road, Shanghai, 200032, China. leexiaoqiu@hotmail.com.
Shanghai Medical College of Fudan University · CNFudan University Shanghai Cancer Center · CN

Funding

natural science foundation of shanghai 11ZR1407100science and technology commission of shanghai municipality 134119a5000
6 · The paper itself

Abstract

backgroundThe distinction between acinic cell carcinoma (ACC) and secretory carcinoma (SC) of the salivary gland is hampered by the lack of specific diagnostic markers. It is known the cytoplasm of glandular cells in the salivary gland immunohistochemically expresses LIM Domain Only 2 (LMO2). Herein, we aim to evaluate the expression status of LMO2 in a large cohort of tumors of the salivary gland, with an emphasis on its significance in the distinction of ACC and SC.

methodsImmunohistochemical stains were performed to evaluate the expression of LMO2 in normal tissues and tumors of salivary gland.

resultsLMO2 was expressed in normal serous acinar cells of the salivary gland. We also found the cytoplasmic immunostaining of LMO2 was specific and sensitive for the recognition of ACCs including those with morphological overlaps with SCs, whereas the cytoplasmic expression of LMO2 was not detected in SCs.

conclusionsLMO2 is useful for the recognition of ACC and is of potential value in distinguishing ACC from SC.

Indexed as

CarcinomaCarcinoma, Acinar CellSalivary Gland NeoplasmsAdaptor Proteins, Signal TransducingBiomarkers, TumorHumansLIM Domain ProteinsProto-Oncogene ProteinsSalivary GlandsAdaptor Proteins, Signal TransducingBiomarkers, TumorLIM Domain ProteinsLMO2 protein, humanProto-Oncogene ProteinsAcinic cell carcinomaLMO2Salivary glandSecretory carcinoma

Identifiers

PMID35094691
PMCPMC8802521
OpenAlexW4210453844

What OpenQuestion holds

Textmetadata
LicenceCC BY
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.