Evidence map›Paper›PMID 35094664›Full record

ArticleTopics in stroke rehabilitation2023

The minimal clinically important difference of the motricity index score.

Chen Lin, Yurany A Arevalo, Richard L Harvey, Shyam Prabhakaran, Kimberly D Martin

Registry-linked trialOpen access · greenAbstract read
PubMed Full text at PMC Publisher
In one paragraph

Article in Topics in stroke rehabilitation, 2023. The graph could read no effect estimate from its abstract, so it casts no vote on the map. It is linked to trial NCT05828160 (Development and Validation of the Italian Version of Modified Barthel Index and of the Motricity Index Scales), which is not on this map. Cited by 6 papers, 1 of them a synthesis that pooled it.

0numbers the graph read from it
0cells of the map it votes in
6citing papers in PubMed, 1 pooled it
0.6field-weighted citation impact, top 32% of its field
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

NCT05828160 unknown statusnot on this map

Development and Validation of the Italian Version of Modified Barthel Index and of the Motricity Index Scales

TypeobservationalSponsorFondazione Don Carlo Gnocchi ETSRan2023 to 2024Enrolled115ConditionsCross-Cultural Comparison, Validation Study, Reliability and Validity, Disability Physical
3 · Its place in the literature

Who cites it

6 citing papers in PubMed, 1 synthesis or guideline pooled it, 6 citations in OpenAlex.

  1. Pooled it
  2. Article
  3. Article
  4. Article
  5. Article
  6. Article
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

5 authors at 3 institutions in 1 country.

Chen LinDepartments of Neurology, The University of Alabama at Birmingham, Birmingham, AL, USA.ORCID 0000-0001-5291-9674
Yurany A ArevaloDepartments of Neurology, The University of Alabama at Birmingham, Birmingham, AL, USA.
Richard L HarveyDepartment of Physical Medicine and Rehabilitation, Northwestern University, Chicago, IL, USA.
Shyam PrabhakaranDepartment of Neurology, The University of Chicago, Chicago, IL, USA.
Kimberly D MartinDepartments of Epidemiology, The University of Alabama at Birmingham, Birmingham, AL, USA.
University of Alabama at Birmingham · USNorthwestern University · USUniversity of Chicago · US

Funding

National Dissemination of I-Corps@NCATS: Accelerating Translation through CommercializationUL1TR003096 · NCATS · UNIVERSITY OF ALABAMA AT BIRMINGHAM · PI GUTIERREZ, ORLANDO M, KIMBERLY, ROBERT P. · 2019 to 2023
$43.6M
Feasibility of combination exercise and neuromodulation rehabilitation to improve post-stroke chronic painI21RX003612 · VA · BIRMINGHAM VA MEDICAL CENTER · PI LIN, CHEN · 2021 to 2023
–
A randomized placebo-controlled trial of methylphenidate in Veterans with a diagnosis of post traumatic stress disorder and recent cerebral stroke.IK2CX002104 · VA · BIRMINGHAM VA MEDICAL CENTER · PI LIN, CHEN · 2021 to 2025
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CSRD VA IK2 CX002104NCATS NIH HHS UL1 TR003096RRD VA I21 RX003612
6 · The paper itself

Abstract

introductionThe Motricity Index (MI) can predict motor function after rehabilitation, but its minimal clinically important difference (MCID) has not been established. The primary study aim was to estimate the MCID value of the MI arm score.

methodsBetween 2017 and 2018, 173 participants hospitalized with confirmed ischemic stroke were recruited into an observational rehabilitation study. Participants with motor weakness as measured by the Fugl-Meyer upper-extremity (FM-UE) and MI with complete baseline and follow-up assessments at 3 months were included in this analysis. The longitudinal recovery of the MI arm score was anchored to having a poor outcome based on the FM-UE recovery (<9) longitudinally. Results reported include the area-under-curve (AUC), along with sensitivity, specificity, and optimal cut-points based on maximizing the Youden statistic.

resultsSixty-nine patients (median [IQR] age 70 [18] years; 48% male; 54% white) were included in the final analysis. Mean ± standard deviation outcome scores at 3-months were: MI arm: 83.19 ± 22.80; FM-UE: 53.04 ± 17.26. For the primary results, the MI arm score optimal MCID cutoff for observed recovery was 13 points with a sensitivity of 80% (95% Confidence Interval (CI)(67.6%, 92.4%)) and a specificity of 69.0% (95% CI (52.1, 85.8%)), and the AUC was 0.8082 (0.7007, 0.9157).

conclusionsThis was the first study to report the MCID of the MI arm score, as anchored to the FM-UE recovery between acute evaluation and 3-months. The estimated optimal MCID of improvement in the MI arm score was 13 points.

Indexed as

StrokeStroke RehabilitationAgedDisability EvaluationFemaleHumansMaleMinimal Clinically Important DifferenceRecovery of FunctionUpper Extremityfunctional outcome measureminimal clinically important differencemotricity indexstroke outcomesStroke rehabilitationupper limb

Identifiers

PMID35094664
PMCPMC9338175
OpenAlexW4210616540

What OpenQuestion holds

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Registered trials

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.