Evidence map›Paper›PMID 35094426›Full record

ArticleJournal of bone and mineral research : the official journal of the American Society for Bone and Mineral Research2022

Bone Microarchitecture and Strength in Long-Standing Type 1 Diabetes.

Lilian Sewing, Laura Potasso, Sandra Baumann, Denis Schenk, Furkan Gazozcu, Kurt Lippuner, Marius Kraenzlin, Philippe Zysset, Christian Meier

Registry-linked trialOpen access · hybridAbstract read
In one paragraph

Article in Journal of bone and mineral research : the official journal of the American Society for Bone and Mineral Research, 2022. The graph could read no effect estimate from its abstract, so it casts no vote on the map. It is linked to trial NCT02551315 (Microarchitecture, Bone Strength and Fracture Risk in Type 2 Diabetes), which is not on this map. Cited by 27 papers.

0numbers the graph read from it
0cells of the map it votes in
27citing papers in PubMed
4.0field-weighted citation impact, top 5% of its field
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

NCT02551315 completednot on this map

Microarchitecture, Bone Strength and Fracture Risk in Type 2 Diabetes: the DiabOS Study

TypeobservationalSponsorUniversity Hospital, Basel, SwitzerlandRan2016 to 2020Enrolled274ConditionsType 2 Diabetes Mellitus, Bone Fractures
3 · Its place in the literature

Who cites it

27 citing papers in PubMed, 48 citations in OpenAlex.

  1. Article
  2. Contributions of Bone Microarchitecture to Skeletal Fragility in Adults with Longstanding Type 1 Diabetes.Journal of bone and mineral research : the official journal of the American Society for Bone and Mineral Research · 2026
    Article
  3. Article
  4. Article
  5. Article
  6. Bone health in children and adolescents with type 1 and type 2 diabetes.Annals of pediatric endocrinology & metabolism · 2025
    Article
  7. Article
  8. Article
  9. Bone microstructure and TBS in diabetes: what have we learned? A narrative review.Osteoporosis international : a journal established as result of cooperation between the European Foundation for Osteoporosis and the National Osteoporosis Foundation of the USA · 2025
    Review
  10. Observational
  11. Assessment of fracture risk in diabetic patients.Journal of diabetes and metabolic disorders · 2024
    Review
  12. Review
  13. Review
  14. Microvascular disease and early diabetes onset are associated with deficits in femoral neck bone density and structure among older adults with longstanding type 1 diabetes.Journal of bone and mineral research : the official journal of the American Society for Bone and Mineral Research · 2024
    Article
  15. Article
  16. Review
  17. Review
  18. Article
  19. Review
  20. Article
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

9 authors at 4 institutions in 1 country.

Lilian SewingDepartment of Endocrinology, Diabetology and Metabolism University Hospital Basel, Basel, Switzerland.ORCID 0000-0001-5321-844X
Laura PotassoDepartment of Endocrinology, Diabetology and Metabolism University Hospital Basel, Basel, Switzerland.
Sandra BaumannDepartment of Endocrinology, Diabetology and Metabolism University Hospital Basel, Basel, Switzerland.
Denis SchenkARTORG Center, University of Bern, Bern, Switzerland.
Furkan GazozcuDepartment of Osteoporosis, University Hospital Bern, Bern, Switzerland.
Kurt LippunerDepartment of Osteoporosis, University Hospital Bern, Bern, Switzerland.ORCID 0000-0002-7195-3779
Marius KraenzlinEndocrine Clinic and Laboratory, Basel, Switzerland.
Philippe ZyssetARTORG Center, University of Bern, Bern, Switzerland.
Christian MeierDepartment of Endocrinology, Diabetology and Metabolism University Hospital Basel, Basel, Switzerland.ORCID 0000-0002-0619-821X
University Hospital of Basel · CHUniversity Hospital of Bern · CHUniversity of Bern · CHUniversity of Basel · CH

Funding

Swiss National Science Foundation
6 · The paper itself

Abstract

Type 1 diabetes (T1DM) is associated with an increased fracture risk, specifically at nonvertebral sites. The influence of glycemic control and microvascular disease on skeletal health in long-standing T1DM remains largely unknown. We aimed to assess areal (aBMD) and volumetric bone mineral density (vBMD), bone microarchitecture, bone turnover, and estimated bone strength in patients with long-standing T1DM, defined as disease duration ≥25 years. We recruited 59 patients with T1DM (disease duration 37.7 ± 9.0 years; age 59.9 ± 9.9 years.; body mass index [BMI] 25.5 ± 3.7 kg/m

Indexed as

Bone ResorptionDiabetes Mellitus, Type 1Fractures, BoneAbsorptiometry, PhotonAgedBiomarkersBone DensityFemur NeckHumansMiddle AgedRadiusTibiaBiomarkersBMDBONE MICROARCHITECTUREBONE STRENGTHBONE TURNOVERTYPE 1 DIABETES

Identifiers

PMID35094426
PMCPMC9313576
OpenAlexW4210310462

What OpenQuestion holds

Textmetadata
LicenceCC BY
Read underepoch 390

Registered trials

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.