ArticleAllergy2022
Characterization of eosinophilic esophagitis variants by clinical, histological, and molecular analyses: A cross-sectional multi-center study.
Article in Allergy, 2022. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 33 papers, 1 of them a synthesis that pooled it.
What it found
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The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.
The trial behind it
Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.
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Who cites it
33 citing papers in PubMed, 1 synthesis or guideline pooled it, 50 citations in OpenAlex.
- AGA Clinical Practice Update on Esophageal Dysfunction Due to Disordered Immunity and Infection: Expert Review.Clinical gastroenterology and hepatology : the official clinical practice journal of the American Gastroenterological Association · 2024Guideline
- Molecular Characterization of Non-Specific Esophagitis Reveals a Distinct Non-Eosinophilic Phenotype With Fibrotic Traits.Allergy · 2026Article
- The Food Allergy-Eosinophilic Esophagitis Continuum: Implications for Food Allergy Immunotherapy.The journal of allergy and clinical immunology. In practice · 2026Review
- Economic burden of eosinophilic esophagitis in the first year after diagnosis in Spain: A direct medical cost analysis.The European journal of health economics : HEPAC : health economics in prevention and care · 2026Observational
- Standardisation of histologic reporting in eosinophilic oesophagitis: Expert recommendations.Pathologica · 2026Review
- Prevalence of dysphagia and eosinophilic esophagitis in patients with inflammatory bowel disease or type 2 inflammation: a cross-sectional multicenter screening study.Therapeutic advances in gastroenterology · 2026Article
- The Therapeutic Pipeline for Eosinophilic Esophagitis: Current Landscape and Future Directions.Pharmaceuticals (Basel, Switzerland) · 2025Review
- Distinct Roles for Thymic Stromal Lymphopoietin (TSLP) and IL-33 in Experimental Eosinophilic Esophagitis.Allergy · 2025Article
- Circulating Food Allergen-Specific Antibodies, Beyond IgG4, Are Elevated in Eosinophilic Esophagitis.Clinical and experimental allergy : journal of the British Society for Allergy and Clinical Immunology · 2025Article
- The Overlap of Allergic Disorders and Upper Gastrointestinal Symptoms: Beyond Eosinophilic Esophagitis.Nutrients · 2025Observational
- [Eosinophilic esophagitis].Innere Medizin (Heidelberg, Germany) · 2025Review
- Narrow band imaging complements eosinophilic esophagitis reference score in predicting inflammatory infiltration in patients with dysphagia.Endoscopy international open · 2025Article
- Introducing ICAM1 as a possible drug target in treatment of eosinophilic esophagitis.Gastroenterology and hepatology from bed to bench · 2025Article
- Rationale for an Eosinophilic Esophagitis Treat-to-Target Concept.Gastroenterology & hepatology · 2024Article
- Diagnosis and management of eosinophilic esophagitis and esophageal food impaction in adults : A position paper issued by the Austrian Society of Gastroenterology and Hepatology (ÖGGH).Wiener klinische Wochenschrift · 2024Article
- Regulation of MYC by CARD14 in human epithelium is a determinant of epidermal homeostasis and disease.Cell reports · 2024Article
- Article
- Development and dysfunction of structural cells in eosinophilic esophagitis.The Journal of allergy and clinical immunology · 2024Review
- Endoscopic Features of Eosinophilic Gastrointestinal Diseases.Immunology and allergy clinics of North America · 2024Review
- A synthesis and subgroup analysis of the eosinophilic esophagitis tissue transcriptome.The Journal of allergy and clinical immunology · 2024Article
Corrections and comments
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Authors and funding
19 authors at 10 institutions in 4 countries.
Funding
Abstract
objectivePhysicians are increasingly confronted with patients presenting with symptoms of esophageal dysfunction resembling eosinophilic esophagitis (EoE), but absence of significant esophageal eosinophilia. The purpose of this study was to characterize and classify this group of EoE variants.
designPatients from six EoE-centers with symptoms of esophageal dysfunction, but peak eosinophil counts of <60/mm
resultsWe included 69 patients with EoE variants. Endoscopic abnormalities were found in 53.6%. We identified three histological subtypes: EoE-like esophagitis (36/69, 52.2%), lymphocytic esophagitis (14/69, 20.3%), and non-specific esophagitis (19/69, 27.5%). Immunohistochemistry revealed-in contrast to EoE-no significant increase in inflammatory cell infiltrates compared with GERD and healthy controls, except for lymphocytes in lymphocytic esophagitis. EoE-typical Th2-response was absent in all EoE variants. However, considerable structural changes were detected based on histology and protein expression. Using next generation mRNA sequencing, we found the three EoE variants to have distinct molecular fingerprints partially sharing pronounced traits of EoE. Hierarchical sample clustering of RNA sequencing data confirmed the presence of an EoE-like (characterized by eotaxin-3 expression), non-specific, and lymphocytic variant cluster (characterized by CD3 cells and TSLP expression).
conclusionAll EoE variants are clinically and histologically active conditions despite the absence of esophageal eosinophilia. EoE variants appear to be part of a disease spectrum, where classical EoE represents the most common and apparent phenotype.
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Registered trials
Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.