Evidence map›Paper›PMID 35094406›Full record

ReviewAllergy2022

Translation and emerging functions of non-coding RNAs in inflammation and immunity.

Elena Della Bella, Jana Koch, Katja Baerenfaller

Abstract readReview
In one paragraph

Review in Allergy, 2022. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 37 papers.

0numbers the graph read from it
0cells of the map it votes in
37citing papers in PubMed
–field-weighted citation impact
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

37 citing papers in PubMed.

  1. Review
  2. Article
  3. Article
  4. Article
  5. Article
  6. Article
  7. Review
  8. Review
  9. Review
  10. Review
  11. Article
  12. Review
  13. Article
  14. Review
  15. Article
  16. Review
  17. LncRNA-encoded peptides in cancer.Journal of hematology & oncology · 2024
    Review
  18. Article
  19. Article
  20. Regulatory RNAs in immunosenescence.Immunity, inflammation and disease · 2024
    Review
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

3 authors.

Elena Della BellaAO Research Institute Davos (ARI), Davos, Switzerland.ORCID 0000-0001-5151-7390
Jana KochSwiss Institute of Allergy and Asthma Research (SIAF), University of Zurich, Swiss Institute of Bioinformatics (SIB), Davos, Switzerland.ORCID 0000-0002-7552-6088
Katja BaerenfallerSwiss Institute of Allergy and Asthma Research (SIAF), University of Zurich, Swiss Institute of Bioinformatics (SIB), Davos, Switzerland.ORCID 0000-0002-1904-9440

Funding

No grant is acknowledged in the PubMed record.

6 · The paper itself

Abstract

Regulatory non-coding RNAs (ncRNAs) including small non-coding RNAs (sRNAs), long non-coding RNAs (lncRNAs), and circular RNAs (circRNAs) have gained considerable attention in the last few years. This is mainly due to their condition- and tissue-specific expression and their various modes of action, which suggests them as promising biomarkers and therapeutic targets. One important mechanism of ncRNAs to regulate gene expression is through translation of short open reading frames (sORFs). These sORFs can be located in lncRNAs, in non-translated regions of mRNAs where upstream ORFs (uORFs) represent the majority, or in circRNAs. Regulation of their translation can function as a quick way to adapt protein production to changing cellular or environmental cues, and can either depend solely on the initiation and elongation of translation, or on the roles of the produced functional peptides. Due to the experimental challenges to pinpoint translation events and to detect the produced peptides, translational regulation through regulatory RNAs is not well studied yet. In the case of circRNAs, they have only recently started to be recognized as regulatory molecules instead of mere artifacts of RNA biosynthesis. Of the many roles described for regulatory ncRNAs, we will focus here on their regulation during inflammation and in immunity.

Indexed as

RNA, Long NoncodingHumansInflammationPeptidesProtein BiosynthesisRNA, CircularPeptidesRNA, CircularRNA, Long Noncodingimmunologyinflammationnon-coding RNAregulationtranslation

Identifiers

PMID35094406
PMCPMC9302665

What OpenQuestion holds

Textmetadata
LicenceCC BY-NC
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.