Observational studyEndocrine2022
Prognostic value of post-ablation stimulated thyroglobulin in differentiated thyroid cancer patients with biochemical incomplete response: a bi-center observational study.
Observational study in Endocrine, 2022. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 6 papers, 1 of them a synthesis that pooled it.
What it found
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The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.
The trial behind it
Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.
Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.
Who cites it
6 citing papers in PubMed, 1 synthesis or guideline pooled it, 9 citations in OpenAlex.
- Pooled it
- Article
- Long-term clinical outcomes of differentiated thyroid cancer patients with biochemical incomplete response after initial radioiodine therapy, a single-center, retrospective analysis.Frontiers in endocrinology · 2026Article
- Locoregional Recurrence after Biochemical Incomplete Response in Differentiated Thyroid Cancer Patients: Insights into Influencing Clinicopathological Factors and the Potential Role ofWorld journal of nuclear medicine · 2025Article
- Impact of thyroglobulin changes on clinical outcomes of differentiated thyroid cancer with biochemical incomplete response.Endocrine · 2025Article
- Incomplete ablation of thyroid cancer: Achilles' Heel?BMC endocrine disorders · 2024Article
Corrections and comments
PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.
Authors and funding
5 authors at 2 institutions in 1 country.
Funding
No grant is acknowledged in the PubMed record.
Abstract
objectiveLittle is known regarding parameters predicting persistence/recurrence for differentiated thyroid cancer (DTC) patients exhibiting biochemical incomplete response (BIR) to initial therapy. High post-ablation stimulated thyroglobulin (ps-Tg) levels have undetermined prognostic significance in DTC patients with BIR. The goal of this bi-center study was to systemically assess the prognosis of DTC patients with BIR in relation to ps-Tg levels and to establish the determinants of clinical outcomes. DESIGN AND
methodsThe retrospective study of consecutive 81 DTC patients from two tertiary centers who were classified as BIR after total thyroidectomy and radioiodine ablation between January 2010 to December 2019 were analyzed. BIR was defined as ps-Tg > 10 ng/mL measured under thyroid hormone withdrawal at 9-12 months followed by radioiodine ablation, negative anti-Tg antibodies, and no structural evidence of disease. Multivariable regression models were used to evaluate potential risk factors associated with clinical outcomes.
resultsWith a median follow-up of 5.4 years, 28 patients (34.6%) showed no evidence of disease and 50 patients (61.7%) were of a biochemical persistent status at the time of final follow-up. Conversely, 3 patients (3.7%) developed structural evidence of disease. Ps-Tg of 20.2 ng/mL or greater displayed the high positive predictive value (81%) for disease persistence/recurrence. Multivariate analysis revealed that only a high ps-Tg level (>20.2 ng/mL) was an independent risk factor for persistent/recurrent disease (odds ratio = 5.6; p < 0.001).
conclusionThe ps-Tg (>20.2 ng/mL) was a valuable predictor of disease persistence/recurrence in DTC patients with BIR.
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