Evidence map›Paper›PMID 35094234›Full record

ArticleBiological trace element research2022

Role of Endoplasmic Reticulum Stress in Nano-Selenium Alleviating Prehierarchical Follicular Atresia Induced by Mercury in Laying Hens.

Yan Ma, Yizhen Shi, Yuqin Wang, Qiujue Wu, Binyao Cheng, Yumeng Li, Zhuosi Wang, Xiaoying Chai, Ao Ren, Gan Li

Abstract read
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In one paragraph

Article in Biological trace element research, 2022. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 4 papers.

0numbers the graph read from it
0cells of the map it votes in
4citing papers in PubMed
1.0field-weighted citation impact, top 28% of its field
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

4 citing papers in PubMed, 10 citations in OpenAlex.

  1. Review
  2. Article
  3. Review
  4. Review
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

10 authors at 1 institution in 1 country.

Yan MaCollege of Animal Science and Technology, Henan University of Science and Technology, Luoyang, 471003, China. yma19880621@163.com.ORCID http://orcid.org/0000-0002-5924-1293
Yizhen ShiCollege of Animal Science and Technology, Henan University of Science and Technology, Luoyang, 471003, China.
Yuqin WangCollege of Animal Science and Technology, Henan University of Science and Technology, Luoyang, 471003, China.
Qiujue WuCollege of Animal Science and Technology, Henan University of Science and Technology, Luoyang, 471003, China.
Binyao ChengCollege of Animal Science and Technology, Henan University of Science and Technology, Luoyang, 471003, China.
Yumeng LiCollege of Animal Science and Technology, Henan University of Science and Technology, Luoyang, 471003, China.
Zhuosi WangCollege of Animal Science and Technology, Henan University of Science and Technology, Luoyang, 471003, China.
Xiaoying ChaiCollege of Animal Science and Technology, Henan University of Science and Technology, Luoyang, 471003, China.
Ao RenCollege of Animal Science and Technology, Henan University of Science and Technology, Luoyang, 471003, China.
Gan LiCollege of Animal Science and Technology, Henan University of Science and Technology, Luoyang, 471003, China.
Henan University of Science and Technology · CN

Funding

PhD Research Start-up Fund of Henan University of Science and Technology 13480086
6 · The paper itself

Abstract

This study investigated that the effect of nano-selenium (nano-Se) addition preventing prehierarchical follicular atresia induced by mercury (Hg) exposure in laying hens. Furthermore, endoplasmic reticulum (ER) stress pathway was explored to reveal the protective mechanism of nano-Se in vitro. The results revealed that Hg could significantly reduce laying performance (P < 0.05) and egg quality (P < 0.05), whereas nano-Se addition partially reversed the reductions. Besides, Hg significantly induced the deposition of Hg in prehierarchical follicles (P < 0.05) and prehierarchical follicular atresia (P < 0.05), whereas nano-Se addition could alleviate these toxicities in vitro. In addition, Hg exposure could significantly reduce cell viability (P < 0.05) and induce pyknotic nucleus in prehierarchical granulosa cells, while nano-Se addition reversed these effects. The levels of follicle-stimulating hormone (P < 0.05), luteinizing hormone (P < 0.05), progesterone (P < 0.05), and estradiol (P < 0.05) were significantly decreased after Hg exposure in vitro. However, nano-Se addition reversed the decreases of sex hormone levels. Furthermore, Hg exposure significantly increased the gene expressions of CHOP (P < 0.05), PERK (P < 0.05), ATF4 (P < 0.05), ATF6 (P < 0.05), ASK1 (P < 0.05), IRE1α (P < 0.05), TRAF2 (P < 0.05), caspase-9 (P < 0.05), caspase-3 (P < 0.05), and Bax/Bcl-2 (P < 0.05), whereas nano-Se addition reversed these increases of gene expressions in vitro. In summary, this study provides that Hg can induce prehierarchical follicular atresia, whereas nano-Se addition can ameliorate it, and elucidates an important role of ER stress in nano-Se alleviating prehierarchical follicular atresia induced by Hg in laying hens.

Indexed as

MercurySeleniumAnimalsbcl-2-Associated X ProteinCaspase 3Caspase 9ChickensEndoplasmic Reticulum StressEndoribonucleasesEstradiolFemaleFollicle Stimulating HormoneFollicular AtresiaLuteinizing HormoneProgesteroneProtein Serine-Threonine Kinasesbcl-2-Associated X ProteinCaspase 3Caspase 9EndoribonucleasesEstradiolFollicle Stimulating HormoneLuteinizing HormoneMercuryProgesteroneProtein Serine-Threonine KinasesSeleniumTNF Receptor-Associated Factor 2Endoplasmic reticulum stressFollicular atresiaLaying hensMercuryNano-selenium

Identifiers

PMID35094234
OpenAlexW4210539539

What OpenQuestion holds

Textmetadata
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.