Evidence map›Paper›PMID 35094221›Full record

ArticleJapanese journal of radiology2022

Anomaly detection in chest

Takahiro Nakao, Shouhei Hanaoka, Yukihiro Nomura, Naoto Hayashi, Osamu Abe

Open access · hybridAbstract read
In one paragraph

Article in Japanese journal of radiology, 2022. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 13 papers.

0numbers the graph read from it
0cells of the map it votes in
13citing papers in PubMed
3.2field-weighted citation impact, top 8% of its field
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

13 citing papers in PubMed, 23 citations in OpenAlex.

  1. Unsupervised anomaly detection for longitudinal comparison in whole-body PET/CT images.International journal of computer assisted radiology and surgery · 2026
    Article
  2. The Evolution and Clinical Impact of Deep Learning Technologies in Breast MRI.Magnetic resonance in medical sciences : MRMS : an official journal of Japan Society of Magnetic Resonance in Medicine · 2025
    Review
  3. Review
  4. Review
  5. Review
  6. Review
  7. Automated screening of computed tomography using weakly supervised anomaly detection.International journal of computer assisted radiology and surgery · 2023
    Article
  8. Review
  9. Current State of Artificial Intelligence in Clinical Applications for Head and Neck MR Imaging.Magnetic resonance in medical sciences : MRMS : an official journal of Japan Society of Magnetic Resonance in Medicine · 2023
    Review
  10. Review
  11. Article
  12. Review
  13. Article
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

5 authors at 2 institutions in 1 country.

Takahiro NakaoDepartment of Computational Diagnostic Radiology and Preventive Medicine, The University of Tokyo Hospital, 7-3-1 Hongo, Bunkyo-ku, Tokyo, 113-8655, Japan. tanakao-tky@umin.ac.jp.ORCID http://orcid.org/0000-0001-9498-7501
Shouhei HanaokaDepartment of Radiology, The University of Tokyo Hospital, 7-3-1 Hongo, Bunkyo-ku, Tokyo, Japan.
Yukihiro NomuraDepartment of Computational Diagnostic Radiology and Preventive Medicine, The University of Tokyo Hospital, 7-3-1 Hongo, Bunkyo-ku, Tokyo, 113-8655, Japan.
Naoto HayashiDepartment of Computational Diagnostic Radiology and Preventive Medicine, The University of Tokyo Hospital, 7-3-1 Hongo, Bunkyo-ku, Tokyo, 113-8655, Japan.
Osamu AbeDepartment of Radiology, The University of Tokyo Hospital, 7-3-1 Hongo, Bunkyo-ku, Tokyo, Japan.
University of Tokyo Hospital · JPChiba University · JP

Funding

Japan Society for the Promotion of Science London JSPS KAKENHI Grant Number 20K22492
6 · The paper itself

Abstract

purposeTo develop an anomaly detection system in PET/CT with the tracer MATERIALS AND

methodsWe trained our model based on a Bayesian deep learning framework using 1878 PET/CT scans with no abnormal findings. Our model learns the distribution of standard uptake values in these normal training images and detects out-of-normal uptake regions. We evaluated this model using 34 scans showing focal abnormal FDG uptake in the chest region. This evaluation dataset includes 28 pulmonary and 17 extrapulmonary abnormal FDG uptake foci. We performed per-voxel and per-slice receiver operating characteristic (ROC) analyses and per-lesion free-response receiver operating characteristic analysis.

resultsOur model showed an area under the ROC curve of 0.992 on discriminating abnormal voxels and 0.852 on abnormal slices. Our model detected 41 of 45 (91.1%) of the abnormal FDG uptake foci with 12.8 false positives per scan (FPs/scan), which include 26 of 28 pulmonary and 15 of 17 extrapulmonary abnormalities. The sensitivity at 3.0 FPs/scan was 82.2% (37/45).

conclusionOur model trained only with normal PET/CT images successfully detected both pulmonary and extrapulmonary abnormal FDG uptake in the chest region.

Indexed as

Deep LearningFluorodeoxyglucose F18Bayes TheoremHumansPositron-Emission TomographyPositron Emission Tomography Computed TomographyRadiopharmaceuticalsFluorodeoxyglucose F18RadiopharmaceuticalsArtificial intelligenceComputer-aided diagnosisDeep learningPositron emission tomographyPositron emission tomography–computed tomography

Identifiers

PMID35094221
PMCPMC9252947
OpenAlexW4210480444

What OpenQuestion holds

Textmetadata
LicenceCC BY
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.