ArticleEuropean archives of oto-rhino-laryngology : official journal of the European Federation of Oto-Rhino-Laryngological Societies (EUFOS) : affiliated with the German Society for Oto-Rhino-Laryngology - Head and Neck Surgery2022
The effect of locally administered phenytoin on wound healing in an experimental nasal septal perforation animal model.
Article in European archives of oto-rhino-laryngology : official journal of the European Federation of Oto-Rhino-Laryngological Societies (EUFOS) : affiliated with the German Society for Oto-Rhino-Laryngology - Head and Neck Surgery, 2022. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 6 papers.
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Who cites it
6 citing papers in PubMed, 10 citations in OpenAlex.
- Evaluation and comparison of the efficacy and safety of the combination of topical phenytoin and microneedling with microneedling alone in the treatment of atrophic acne scars: A controlled blinded randomized clinical trial.Skin research and technology : official journal of International Society for Bioengineering and the Skin (ISBS) [and] International Society for Digital Imaging of Skin (ISDIS) [and] International Society for Skin Imaging (ISSI) · 2024Trial
- Eucalyptol (1,8-Cineole) Enhances Wound Healing in Nasal Septal Perforations: An Experimental Rat Model Study.Laryngoscope investigative otolaryngology · 2025Article
- Effects of Myroxylon pereirae, Phenytoin, and Clinoptilolite After Pharyngocutaneous Fistula: An Experimental Animal Model.Otolaryngology--head and neck surgery : official journal of American Academy of Otolaryngology-Head and Neck Surgery · 2025Article
- A Novel Effect ofLaryngoscope investigative otolaryngology · 2025Article
- Effect of basic fibroblast growth factor with collagen/gelatin fixture in a rabbit model of nasal septum perforation.Regenerative therapy · 2024Article
- The Wound-Healing Potential ofMetabolites · 2022Article
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Authors and funding
2 authors at 2 institutions in 1 country.
Funding
No grant is acknowledged in the PubMed record.
Abstract
purposeIn the present study, we aimed to investigate the effect of phenytoin (PHT) on wound healing in an experimental nasal septal perforation (NSP) model created in rats.
methodsTwenty-two Sprague Dawley male rats were randomized into two groups. NSP, approximately 2 mm in diameter, was created in each subject. The 1% PHT cream (Study group) and saline (Control group) were applied topically once a day for 14 days. The subjects were sacrificed at the end of 14th day and the nasal septum of each animal was excised for histopathological examination. The epithelial regeneration and degeneration of the nasal mucosa, acute inflammatory cells number, fibroblast number, collagen density, vascularization, eosinophil number, granulation tissue formation, giant cell number, degeneration and regeneration of the nasal cartilage were examined. The macroscopic closure rate of NPSs and histopathological parameters were analyzed statistically.
resultsIn this study, the epithelial regeneration, the fibroblast count, the collagen density, the vascularization and the amount of granulation tissue and the macroscopic clouse rate of NSPs were significantly higher in the PHT group than in the saline group (p < .05). There was no significant difference was in other comparisons (p > .05).
conclusionThe locally administered phenytoin may accelerate wound healing of nasal septum in an experimental NSP model. Consequently, phenytoin might be used as an effective substance to prevent the formation of NSP.
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