Evidence map›Paper›PMID 35094036›Full record

ArticleLab on a chip2022

Size and density measurements of single sickle red blood cells using microfluidic magnetic levitation.

Utku Goreke, Allison Bode, Sena Yaman, Umut A Gurkan, Naside Gozde Durmus

Abstract read
In one paragraph

Article in Lab on a chip, 2022. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 16 papers, 1 of them a synthesis that pooled it.

0numbers the graph read from it
0cells of the map it votes in
16citing papers in PubMed, 1 pooled it
–field-weighted citation impact
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

16 citing papers in PubMed, 1 synthesis or guideline pooled it.

  1. Pooled it
  2. bioRxiv : the preprint server for biology · 2026
    Article
  3. Article
  4. Article
  5. Dynamic and precise electromagnetic levitation of single cells.Proceedings of the National Academy of Sciences of the United States of America · 2025
    Article
  6. Article
  7. Article
  8. Article
  9. Motion Blur Microscopy.bioRxiv : the preprint server for biology · 2024
    Article
  10. Article
  11. Article
  12. Article
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4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

5 authors.

Utku GorekeDepartment of Mechanical and Aerospace Engineering, Case Western Reserve University, Cleveland, OH, USA.ORCID 0000-0001-7973-9120
Allison BodeDepartment of Mechanical and Aerospace Engineering, Case Western Reserve University, Cleveland, OH, USA.ORCID 0000-0002-6211-4885
Sena YamanMolecular Imaging Program at Stanford (MIPS), Department of Radiology, Stanford University, Stanford, CA 94304, USA. gdurmus@stanford.edu.ORCID 0000-0002-0388-8901
Umut A GurkanDepartment of Mechanical and Aerospace Engineering, Case Western Reserve University, Cleveland, OH, USA.ORCID 0000-0002-0331-9960
Naside Gozde DurmusMolecular Imaging Program at Stanford (MIPS), Department of Radiology, Stanford University, Stanford, CA 94304, USA. gdurmus@stanford.edu.ORCID 0000-0002-7956-5666

Funding

Standardized Monitoring of Cellular Adhesion to Improve Clinical Care in Sickle Cell DiseaseR01HL133574 · NHLBI · CASE WESTERN RESERVE UNIVERSITY · PI GURKAN, UMUT A., LITTLE, JANE · 2016 to 2020
$2.0M
Clinical Microfluidic Assessment of Red Blood Cell Adhesion, Deformability, Cellular Hemoglobin Distribution, Cellular Density, and Blood Rheology for Curative Therapies in Sickle Cell DiseaseOT2HL152643 · NHLBI · CASE WESTERN RESERVE UNIVERSITY · PI GURKAN, UMUT A. · 2019 to 2021
$1.9M
NHLBI NIH HHS OT2 HL152643NHLBI NIH HHS R01 HL133574
6 · The paper itself

Abstract

Single cells have unique biophysical signatures that can rapidly change during various disease states. For instance, cellular density is an inherent property differing between cell types. Characterizing changes in fundamental density properties down to the single-cell level can reveal sub-populations in pathological states. Here, we have developed a microfluidic, magnetic levitation-based assay (MagDense) that detects minute density differences of individual red blood cells (RBCs) down to 0.0001 g mL

Indexed as

Anemia, Sickle CellMicrofluidicsErythrocyte CountErythrocytesHumansMagnetic Phenomena

Identifiers

PMID35094036
PMCPMC9053311

What OpenQuestion holds

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Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.