ArticlePediatric research2022
Differential age-dependent development of inter-area brain connectivity in term and preterm neonates.
Article in Pediatric research, 2022. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 9 papers.
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9 citing papers in PubMed, 12 citations in OpenAlex.
- The relationship between sonographically assessed volumetric brain development in VLBW preterm infants and neurodevelopmental outcome at 2 years of age-data from the NeoNEVS project.Frontiers in pediatrics · 2026Article
- Brain network evolution in late preterm to term infants: a near-infrared spectroscopy imaging study.Neurophotonics · 2025Article
- Monitoring neonatal brain function: recent advances in functional near-infrared spectroscopy (fNIRS).Frontiers in pediatrics · 2025Review
- Sleep state-dependent development of resting-state functional connectivity during the preterm period.Sleep · 2024Article
- Functional reorganization of brain regions supporting artificial grammar learning across the first half year of life.PLoS biology · 2024Article
- [Research progress on brain functional near-infrared spectroscopy technology in the field of neonates].Zhongguo dang dai er ke za zhi = Chinese journal of contemporary pediatrics · 2024Review
- Using functional near-infrared spectroscopy to study the early developing brain: future directions and new challenges.Neurophotonics · 2023Article
- Effects of Hemodynamic Differences on the Assessment of Inter-Brain Synchrony Between Adults and Infants.Frontiers in psychology · 2022Article
- [Early resting-state functional connectivity characteristics in preterm and full-term infants: an exploratory study using functional near-infrared spectroscopy].Zhongguo dang dai er ke za zhi = Chinese journal of contemporary pediatricsArticle
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6 authors at 1 institution in 1 country.
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Abstract
backgroundAmong preterm infants, higher morbidities of neurological disturbances and developmental delays are critical issues. Resting-state networks (RSNs) in the brain are suitable measures for assessing higher-level neurocognition. Since investigating task-related brain activity is difficult in neonates, assessment of RSNs provides invaluable insight into their neurocognitive development.
methodsThe participants, 32 term and 71 preterm neonates, were divided into three groups based on gestational age (GA) at birth. Cerebral hemodynamic activity of RSNs was measured using functional near-infrared spectroscopy in the temporal, frontal, and parietal regions.
resultsHigh-GA preterm infants (GA ≥ 30 weeks) had a significantly stronger RSN than low-GA preterm infants and term infants. Regression analyses of RSNs as a function of postnatal age (PNA) revealed a steeper regression line in the high-GA preterm and term infants than in the low-GA infants, particularly for inter-area brain connectivity between the frontal and left temporal areas.
conclusionsSlower PNA-dependent development of the frontal-temporal network found only in the low-GA group suggests that significant brain growth optimal in the intrauterine environment takes place before 30 weeks of gestation. The present study suggests a likely reason for the high incidence of neurodevelopmental impairment in early preterm infants. IMPACT: Resting-state fNIRS measurements in three neonate groups differing in gestational age (GA) showed stronger networks in the high-GA preterm infants than in the term and low-GA infants, which was partly explained by postnatal age (PNA). Regression analyses revealed a similar PNA-dependence in the development of the inter-area networks in the frontal and temporal lobes in the high-GA and term infants, and significantly slower development in the low-GA infants. These results suggest that optimal intrauterine brain growth takes place before 30 weeks of gestation. This explains one of the reasons for the high incidence of neurodevelopmental impairment in early preterm infants.
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