ArticleMedical principles and practice : international journal of the Kuwait University, Health Science Centre2022
Red Cell Distribution Width Is Independently Associated with Mortality in Sepsis.
Article in Medical principles and practice : international journal of the Kuwait University, Health Science Centre, 2022. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 31 papers, 2 of them syntheses that pooled it.
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Who cites it
31 citing papers in PubMed, 2 syntheses or guidelines pooled it.
- Red blood cell distribution width as a predictor of mortality in critically ill pediatric patients: a systematic review and meta-analysis.Frontiers in pediatrics · 2025Pooled it
- Diagnostic value of RDW for the prediction of mortality in adult sepsis patients: A systematic review and meta-analysis.Frontiers in immunology · 2022Pooled it
- Article
- Comparison of predictive values of Acute Physiology and Chronic Health Evaluation scores for mortality in sepsis: a systematic review and meta-analysis.World journal of emergency medicine · 2026Review
- A single postoperative red cell distribution width measurement predicts short- and long-term mortality in surgical patients.Wiener medizinische Wochenschrift (1946) · 2026Article
- Association between red cell distribution width-to-albumin ratio and sepsis-associated acute kidney injury.BMC nephrology · 2026Article
- Explainable machine learning model for predicting short-term outcomes in sepsis- induced coagulopathy.BMC medical informatics and decision making · 2026Article
- Association between admission hemoglobin-to-red blood cell distribution width ratio and stroke-associated pneumonia risk in acute ischemic stroke: effect modification by diabetes status.Frontiers in endocrinology · 2026Article
- Predicting sepsis prognosis using deep learning with routine biomarkers.Frontiers in medicine · 2026Article
- Red blood cell distribution width to albumin ratio predicts mortality in heart failure patients with pneumonia.Frontiers in cardiovascular medicine · 2026Article
- Risk Factors and Development of a Predictive Model for In-Hospital Mortality in Hemodynamically Stable Older Adults with Urinary Tract Infection.Medicina (Kaunas, Lithuania) · 2025Article
- Red cell distribution width and clinical outcomes in sepsis patients infected with Escherichia coli using data from MIMIC-IV.European journal of medical research · 2025Article
- Combined glycated hemoglobin index and red cell distribution width predict in-hospital mortality in critically ill sepsis patients based on MIMIC-IV analysis.Scientific reports · 2025Article
- Prioritizing Patient Selection in Clinical Trials: A Machine Learning Algorithm for Dynamic Prediction of In-Hospital Mortality for ICU Admitted Patients Using Repeated Measurement Data.Journal of clinical medicine · 2025Article
- Association between red cell distribution width to albumin ratio and all-cause mortality in patients with acute pancreatitis admitted to the intensive care unit: a retrospective study based on the MIMIC-IV database.Frontiers in medicine · 2025Article
- Association between red blood cell distribution width and encephalitis based on the pediatric intensive care unit database: a cross-sectional study.Frontiers in neurology · 2025Article
- Insights of red cell distribution width for mortality in septic patients with diabetes mellitus: A multicenter cohort study.PloS one · 2025Article
- Roles of cytokine storm in sepsis progression: biomarkers, and emerging therapeutic strategies.Frontiers in immunology · 2025Review
- Prediction of the need for surgery in patients with unruptured abdominal aortic aneurysm based on SOFA score.PloS one · 2025Article
- Red blood cell distribution width to albumin ratio as a predictor of mortality in ICU patients with community acquired bacteremia.Scientific reports · 2024Observational
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7 authors.
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Abstract
backgroundMortality in sepsis remains high. Studies on small cohorts have shown that red cell distribution width (RDW) is associated with mortality. The aim of this study was to validate these findings in a large multicenter cohort.
methodsWe conducted this retrospective analysis of the multicenter eICU Collaborative Research Database in 16,423 septic patients. We split the cohort in patients with low (≤15%; n = 7,129) and high (>15%; n = 9,294) RDW. Univariable and multivariable multilevel logistic regressions were used to fit regression models for the binary primary outcome of hospital mortality and the secondary outcome intensive care unit (ICU) mortality with hospital unit as random effect. Optimal cutoffs were calculated using the Youden index.
resultsPatients with high RDW were more often older than 65 years (57% vs. 50%; p < 0.001) and had higher Acute Physiology and Chronic Health Evaluation (APACHE) IV scores (69 vs. 60 pts.; p < 0.001). Both hospital (adjusted odds ratios [aOR] 1.18; 95% CI: 1.16-1.20; p < 0.001) and ICU mortality (aOR 1.16; 95% CI: 1.14-1.18; p < 0.001) were associated with RDW as a continuous variable. Patients with high RDW had a higher hospital mortality (20 vs. 9%; aOR 2.63; 95% CI: 2.38-2.90; p < 0.001). This finding persisted after multivariable adjustment (aOR 2.14; 95% CI: 1.93-2.37; p < 0.001) in a multilevel logistic regression analysis. The optimal RDW cutoff for the prediction of hospital mortality was 16%.
conclusionWe found an association of RDW with mortality in septic patients and propose an optimal cutoff value for risk stratification. In a combined model with lactate, RDW shows equivalent diagnostic performance to Sequential Organ Failure Assessment (SOFA) score and APACHE IV score.
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